I had never heard of Osmosis Jones before, but I grew up watching the animated series based on this movie so I went into it with excitement and a nostalgic drive.
What I got was rather mixed. Let me explain.
The live-action parts pretty much sucked in my opinion. This guy named Frank (Bill Murray) is a single father taking care of his daughter and is a really unlikable father figure. How are we supposed to sympathise with a lazy and egotistical doof? I never felt sorry for him one minute. Mix that with gross-out humour which wasn't even helped the slightest by Bill Murray who is usually really funny.
Enough said about that, because the animated segments were actually pretty awesome. The world inside Frank's was impressive by how it was crafted. How it functions by having a whole community run by a mayor (William Shatner) and a police force of white blood cells and a lot of real-life city stuff showcased a lot of creative effort was put into it.
It centers on a white blood cells Osmosis Jones (Chris Rock) who is that kind of cop who does things his own way and the others at the police station do not approve of his ways, but he is later assigned to a new case with a partner to keep him on track, a cold pill named Drix (David Hyde Pierce). Sure, it follows all the buddy cop movie clichés with nothing new added, but the world they must explore and the colorful characters they meet make it entertaining albeit predictable.
Speaking of the colorful cast of characters, the most interesting and memorable of them all has to be the villian Thrax (Laurence Fishburne) who is menacing and merciless and has a deathcount very high for a PG rated movie.
Without being boring I found that Chris Rock and David Hyde Pierce seemed to do their usual schtick with Rock being hip and a loudmouth and Hyde Pierce doing his quirky and excentric british gentleman voice. But Fishburne surprised me. He could as easily just have put on his Morpheus voice, but he didn't. I'll give him more credit for that.
The live-action segments is the movie's biggest drawbacks with an unlikable main character and lowbrow humour as you would expect from the farelly brothers, and frankly (no pun intented) the animated segments aren't perfect and the transitions between the two don't always work.
But overall Osmosis I found Osmosis Jones enjoyable, but flawed. I understand why it failed in theaters, but I have seen so much worse elsewhere.
