It's an unusually intelligent storyline for a horror flick. In short, what are the ethical limits to scientific experimentation, even in finding a cure for cancer. Using what is now called "cryogenics", Dr. Kravaal (Karloff) crowds those limits while experimenting with a cancer cure on a remote island. Unfortunately, the promising experiments require live subjects who may not be so lucky. Dr. Mason (Pryor), one of the men trapped on the island with Kravaal, is torn by Kravaal's challenge to conventional ethics. So he's the one we sympathize with as we struggle with the same dilemma-- just how much can be sacrificed in finding a cure.
By no means does Karloff ham up his role. Instead he's perfect as a dedicated and distinguished medical scientist, more obsessed than evil. Except for actor Brown's overdone Adams, the rest of the cast also manages conflicted roles. Credit Columbia for the riveting sets-- for example, the cabin about to be eaten by dead plants, the many dingy underground scenes that really do look subterranean, the laboratory that really looks worked in. All in all, it's an unusually well mounted flick for its subject matter. If there's a problem, it's with the absence of a clear bad guy to heighten a sense of horror amid the dark surroundings. I don't get a sense of menace common to the genre. Instead, the 74-minutes is more like a "think piece", which all in all, may be more worthwhile than a good scare.