| Entry |
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| Name |
IGF-IGF1R-RAS-ERK signaling pathway
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| Definition |
IGF -> IGF1R -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
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| Expanded |
(3479,3481) -> 3480 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 3479 | IGF1; insulin like growth factor 1 |
| 3481 | IGF2; insulin like growth factor 2 |
| 3480 | IGF1R; insulin like growth factor 1 receptor |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Reference |
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| Authors |
Aaltonen KE, Rosendahl AH, Olsson H, Malmstrom P, Hartman L, Ferno M |
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| Title |
Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer. |
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| Journal |
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| Reference |
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| Authors |
Iams WT, Lovly CM |
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| Title |
Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade. |
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| Journal |
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| LinkDB |
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