polygene
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(n)
polygene
a gene that by itself has little effect on the phenotype but which can act together with others to produce observable variations
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polygene
Noting those volcanic cones which are the result of successive eruptions: contrasted with monogene. The term was suggested by A. Stübel.
Polygenic Risk, Rapid Childhood Growth, and the Development of ObesityEvidence From a 4-Decade Longitudinal Study. archpedi.ama-assn.org
Polygenic Risk, Rapid Childhood Growth, and the Development of Obesity. archpedi.ama-assn.org
Crow JF, Aoki K (1982) Group selection for a polygenic behavioral trait: differential proliferation model.
Altruism can proliferate through group/kin selection despite high random gene flow
Our modeling takes into account the possibility that apart from QTL the trait can be influenced by a large number of polygenes, i.e. genes with very small effects, distributed over the entire genome.
A comparison of the Benjamini-Hochberg procedure with some Bayesian rules for multiple testing
If our main interest is in identifying markers linked to QTL we consider a sparse mixture (2.1), where p is small and N (0, σ2 ) represents the distribution of the sum of polygenic and random (environmental) effects.
A comparison of the Benjamini-Hochberg procedure with some Bayesian rules for multiple testing
The second component in the mixture, namely N (0, σ2 + τ 2 ), represents the distribution of the QTL effect, µi , and the sum of polygenic and random effects.
A comparison of the Benjamini-Hochberg procedure with some Bayesian rules for multiple testing
If our main interest is in both QTL and polygenic effects, the null component, N (0, σ2 ), represents the distribution of random effects, and N (0, τ 2 ), represents the distribution of effects due to QTL and polygenes.
A comparison of the Benjamini-Hochberg procedure with some Bayesian rules for multiple testing