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The fire station on London Road opened in 1906. It had a complement of 30 men, 10 horses and 6 fire engines. The first motorised fire appliance did not appear until 1911. In addition to a fire station with accompanying workshops, stables and control room, the site also housed a police station, an ambulance station, a bank, a Coroner's Court, and a gas-meter testing station as well as housing for the fire chief and his deputy and apartments for 32 firemen's families who were provided with a gymnasium, laundry, children's play area and a billiard room.

The building was Grade II* listed in 1974 Link and in 2001, it was placed on English Heritage's Buildings at Risk Register.

The premises began a gradual wind-down in 1974 and closed as a fire station in 1986 when it was sold to Britannia Hotels who proposed turning it into a luxury hotel but no plans actually materialised.

In 2013 the group Friends of London Road Fire Station Link was formed. It is a community trust working to bring the London Road Fire Station in Manchester back into positive use through a sympathetic, multi-purpose redevelopment for the benefit of the community – as soon as possible.

In 2015 the building was purchased by the group Allied London Link and serious restoration work began in 2018.