6 days ago · Loss of cilia correlates with an inability to sense and respond to Sonic hedgehog (Shh) signals (Dhekne et al, 2018) that require cilia for signal transduction ...

Sep 29, 2024 · Dhekne, H. S. et al. Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase. eLife 12, e87098 (2023).

Dec 1, 2023 · The Roc domain is a bona fide GTPase that hydrolyzes GTP and undergoes nucleotide-dependent conformational changes reminiscent of the canonical GTPase [24]. The ...

Feb 13, 2024 · Mutations in the LRRK2 gene cause familial Parkinson's disease presenting with pleomorphic neuropathology that can involve α-synuclein or tau accumulation.

Jun 1, 2024 · P. S. Dhekne. One of the most significant threats faced by enterprise networks today is from Bots. A Bot is a program that operates as an agent for a user ...

Sep 16, 2024 · The vesicular pRab12 staining in basal forebrain cholinergic neurons is consistent with an early defect in de novo cilia formation (Dhekne et al., 2018; Lara ...

Aug 2, 2024 · Activating mutations in leucine-rich repeat kinase 2 (LRRK2) represent the most common cause of monogenic Parkinson's disease. LRRK2 is a large multidomain ...

Jan 16, 2024 · These data strongly suggest that loss of cilia in specific striatal cell types decreases neuroprotection for dopamine neurons in mice and human Parkinson's ...

Aug 6, 2024 · These data strongly suggest that loss of cilia in specific striatal cell types decreases neuroprotection for dopamine neurons in mice and human Parkinson's.

Mar 21, 2024 · We find that increased phosphorylation of RAB3A, a cardinal synaptic vesicle precursor (SVP) protein, disrupts anterograde axonal transport of SVPs in iPSC- ...