Oct 23, 2024 · These statistics are subsequently unified across different SA-GWAS to form TA-gene summary statistics, using the ARTP framework for the pathway analysis.

Oct 28, 2024 · In this work, we propose permGWAS2, an improved version of permGWAS that uses a new permutation approach that takes into account the population structure during ...

7 days ago · This study utilized GWAS summary data at both the SNP and gene levels to conduct a comprehensive pleiotropic analysis of four major psychiatric disorders ( ...

Nov 8, 2024 · To conduct imputation- based PWAS, we trained genotype-based protein prediction models for protein levels measured from whole blood samples from the Multi- ...

Oct 25, 2024 · MIRAGE uses an empirical Bayes approach, combining information across genes to estimate these prior probabilities. We demonstrate in both simulations and ...

2 days ago · Overall, we reveal that our new approach to understanding complex traits, involving the integration of high-resolution molecular datasets with genetic- ...

Nov 5, 2024 · In this study, we analysed genome-wide association study (GWAS) summary statistics from five international consortia (n = 158 380) to investigate genetic ...

Nov 9, 2024 · This review aims to provide a comprehensive roadmap for the post-GWAS characterization of POAG genes. We integrate current knowledge from GWAS, ExWAS, and post- ...

Nov 7, 2024 · Genome-wide association studies (GWAS) led to the identification of genes that contribute to complex phenotypes [7]. Previously, we have performed a look-up ...

6 days ago · “Genome‑wide Association of Copy‑Number Variation Reveals an ... “Flexible statistical methods for estimating and testing effects in genomic studies with.