Neuromuscular blocking agents are potent muscle relaxants typically only used during surgery to prevent muscle movement. They are structurally related to acetylcholine (the main neurotransmitter in the body) and they cause muscle relaxation by binding to acetylcholine receptors postsynaptically (which prevents acetylcholine from binding).

Apr 5, 2022 · Neuromuscular blocking drugs are medications that induce paralysis. Complete muscle relaxation permits easier tracheal intubation, which is insertion of a breathing tube into the trachea. Intubation is done prior to initiating mechanical ventilation (breathing machine use) in someone having surgery or critically ill patients.

Jan 7, 2025 · Paralytic drugs, or neuromuscular blocking agents (NMBAs), are powerful muscle relaxants used to prevent muscle movement during surgical procedures. They're also used during critical care, such as when a person is intubated and placed on a ventilator due to severe respiratory illness.

Neuromuscular-blocking drugs, or Neuromuscular blocking agents (NMBAs), block transmission at the neuromuscular junction, [1] causing paralysis of the affected skeletal muscles. This is accomplished via their action on the post-synaptic acetylcholine (Nm) receptors.

Jun 8, 2024 · Medications like calcium channel blockers, lithium, cyclosporine, and anti-arrhythmic drugs such as procainamide and quinidine can increase sensitivity to neuromuscular blocking agents.

Jan 6, 2025 · Neuromuscular blocking agents (NMBAs) are a class of drugs that prevent nerve impulses from reaching muscles, effectively causing temporary paralysis of the skeletal muscles.

May 1, 2023 · Neuromuscular blocking agents are commonly used to paralyze patients requiring intubation whether in an emergency as a life-saving intervention or as a scheduled surgery and procedure.

Nov 13, 2023 · Neuromuscular blockade is frequently used in anesthesia to facilitate endotracheal intubation, optimize surgical conditions, and assist with mechanical ventilation in patients with reduced lung compliance.

Neuromuscular blocking agents (NMBAs) paralyze skeletal muscles by blocking the transmission of nerve impulses at the myoneural junction. NMBAs may be useful in the intensive care unit (ICU) for several indications. The clinical use, administration, and potential adverse effects of NMBAs in critically ill patients will be discussed here.

Sep 1, 2017 · Overview: Neuromuscular blocking agents are used in the ICU setting for 3 reasons: (1) to eliminate spontaneous breathing and promote mechanical ventilation (eg eliminate urge to fight the vent. (2) Cause a pharmacologic restraint so patients do not harm themselves. (3) To decrease oxygen consumption.