Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene. [5] [6] [7] Also known as the ubiquitin-binding protein p62, [8] it is an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy.

May 15, 2019 · SQSTM1/p62 is a scaffold protein closely involved in the macroautophagy process. p62 functions to anchor the ubiquitinated proteins to the autophagosome membrane, promoting degradation of unwanted molecules.

The protein Sequestosome 1 (p62/SQSTM1) is a classical selective autophagy receptor, but it also has roles in the ubiquitin-proteasome system, cellular metabolism, signaling, and apoptosis. p62 is best known for its role in clearing protein aggregates via aggrephagy, but it has recently emerged as a receptor for other forms of selective ...

Dec 25, 2024 · SQSTM1 (Sequestosome 1) is a Protein Coding gene. Diseases associated with SQSTM1 include Paget Disease Of Bone 3 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3. Among its related pathways are p75 NTR receptor-mediated signalling and Selective autophagy.

Feb 14, 2022 · The protein Sequestosome 1 (p62/SQSTM1) is a classical selective autophagy receptor, but it also has roles in the ubiquitin-proteasome system, cellular metabolism, signaling, and apoptosis. p62 is best known for its role in clearing protein aggregates via aggrephagy, but it has recently emerged as a receptor for other forms of selective ...

Nov 7, 2024 · We recently reported that the macroautophagy/autophagy receptor SQSTM1/p62, functions as a novel Ub sensor to activate autophagy upon Ub + stress (upregulation of the Ub level). First, SQSTM1 was found to undergo extensive ubiquitination and activate autophagy under Ub + stress induced by prolonged Bortezomib (BTZ) treatment, Ub overexpression ...

Nov 5, 2018 · Sequestosome 1 (SQSTM1; also known as p62) is conserved in metazoans, and autophagy – the process with which SQSTM1 is primarily associated – is conserved throughout the eukaryotes (Reggiori and Klionsky, 2002; Svenning et al., 2011).

Many gene mutations change single protein building blocks (amino acids) in the p62 protein. The most common mutation replaces the amino acid proline with the amino acid leucine at protein position 392 (written as Pro392Leu or P392L).

May 11, 2021 · Sequestosome-1 (SQSTM1/p62) is involved in cellular processes such as autophagy and metabolic reprogramming. Mutations resulting in the loss of function of SQSTM1 lead to neurodegenerative diseases including frontotemporal dementia.

Apr 23, 2020 · p62/SQSTM1, encoded by gene SQSTM1, is widely known as an adaptor protein of selective autophagy to promote aggregate-prone proteins for degradation. It is also a stress-induced scaffold protein involved in Nrf2 activation to resist oxidative stress.