Nature4y
Glycan-masked Engineered Outer Domains of HIV-1 GP120 and Their Use: Collaborative and Licensing Opportunity
The VRC01-class of potent, broadly neutralizing antibodies (bnAbs) targets the conserved CD4-binding site (CD4bs) of HIV-1 Env which has been a major target of HIV-vaccine design. The current best ...
Nature4y
Recombinant HIV-1 Envelope Protein for Vaccine Use - Licensing and Collaboration Opportunity
Researchers at the Vaccine Research Center (“VRC”) have determined the three-dimensional structure of the HIV-1 Envelope trimeric ectodomain (“Env”), comprised of three gp120 and three ...
Medscape4d
Role of CXCR4 in HIV Infection and its Potential as a Therapeutic Target
Determinants of HIV cell tropism & chemokine receptor usage The V3 loop of HIV-1 gp120 is a primary determinant of cell tropism and chemokine receptor usage, whereas the V1/V2 region is involved ...