Familial adenomatous polyposis of the colon is an autosomal dominant inherited disorder caused by mutations in the tumor suppressor gene adenomatous polyposis coli (APC). A characteristic of this ...
Genetic sequencing revealed a high prevalence of mutations to the organoids’ previously functional APC allele. This is known in cancer biology as loss of heterozygosity, and is reported in nearly 80 ...
Total neoadjuvant therapy with FOLFOX plus bevacizumab and short-course radiotherapy for Ras mutant, high-risk, locally advanced rectal cancer: The TRAINER trial. Phase Ib study of gevokizumab (GEVO) ...
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