In addition to having good technique, a wushu athlete who wants to achieve optimal performance must also have a high level of body fitness. One component that can be used to measure fitness is endurance (Endurance). VO2Max is a measure that can be used to assess endurance, which is the body's ability to be able to breathe oxygen optimally during strenuous physical activity. Research results (Zawawi, 2021)in wushu athletes in Kediri city showed that 42.86% of wushu athletes turned out to have (VO2Max) with less category. This study aims to determine the most dominant factors related to the body fitness of Saburai Lampung wushu adolescent athletes. The research design used was cross sectional with a total sample of the population, which was 20 people. Data collection was conducted by means of interviews to determine age, sex, smoking habits, and supplement use, while measurements were used to determine nutritional status, body type, and VO2Max. Bivariate analysis using correlation test Rank Spearman and multivariate analysis using multiple logistic regression tests. The results of this study showed that there were 6 people (30%) wushu athletes who had body fitness with less categories. Then there is a very strong relationship between age and VO2Max (p = 0.007; correlation coefficient = 0.728), there is a strong relationship between nutritional status and VO2Max (p = 0.004; correlation coefficient = 0.655), there is a very strong relationship between smoking and VO2Max (p = 0.009; correlation coefficient = -0.800), and there is a sufficient relationship between body type (somatotype) and VO2Max (p = 0.016; correlation coefficient = 0.480). Sex was not associated with VO2Max (p = 0.160), and supplement use was not associated with VO2Max (p = 0.124). Nutritional status is known to be the most dominant factor associated with VO2Max (p = 0.001; OR = 7.025). To increase VO2Max, Saburai Lampung wushu athletes need to maintain good nutritional status through the consumption of nutritious, diverse, and balanced foods every day.

In this article, the authors focus on the practical aspects of preparing consolidated financial statements based on international standards, which widely use induction and deduction, monographic observation, factor analysis, synthesis and other methods.

The study was for the period from September 1 to December 1, 2022, when (60) samples were collected, divided into two groups, a control group of 30 people and 30 people for a group of plaque psoriasis. Medical outpatient clinics. All of the oxidative stress represented by MDA and the antioxidants catalase enzyme CAT were measured, as well as the study of immunological variables represented by the rate of alpha tumor necrosis factor (TNF-a) and the rate of interleukin IL-18. The results showed a significant increase in malondaldehyde (MDA), catalase enzyme (CAT), tumor necrosis factor-alpha (TNF-a) and interleukin (IL-18). Compared to the control group at a significant level of P ≤ 0.05.

Migraine is the second most common cause of headache and the most common headache related and indeed neurologic cause of disability in the world. In the global burden of disease study 2010, it was ranked as the third most prevalent disorder in the world. Migraine affects a substantial minority of the population, occurs in all civilizations, and has been recognised since the dawn of recorded history. the definite cause of the migraine is yet to be unknown. Homoeopathy is based on specific principle i.e "similia similibus curenture". It is specialized method of curing the sufferings of person by administration of drugs internally which have been proved experimentally to possess power of producing similar sufferings in a healthy human being. In allopathy, the is only symptomatic treatment for migraine which may give temporary relief from time to time but a complete cure may not be possible, while homoeopathic constitutional medicines cure the migraine permanently. the perpose of this article is to acknowledge the clinical presentation of migraine and to known the homoeopathic management for it. Dr. Jinal Malani | Dr. Anjali R Gupta "Homoeopathy in the Treatment of Migraine-Headache" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-4, August 2023, URL: https://www.ijtsrd.com/papers/ijtsrd59666.pdf Paper Url:https://www.ijtsrd.com/medicine/ayurvedic/59666/homoeopathy-in-the-treatment-of-migraineheadache/dr-jinal-malani

Perturbed cellular protein homeostasis (proteostasis) and mitochondrial dysfunction play an important role in neurodegenerative diseases, however, the interplay between these two phenomena remains unclear. Mitochondrial dysfunction leads to a delay in mitochondrial protein import, causing accumulation of non-imported mitochondrial proteins in the cytosol and challenging proteostasis. Cells respond by increasing proteasome activity and molecular chaperones in yeast and C. elegans. Here, we demonstrate that in human cells mitochondrial dysfunction leads to the upregulation of a chaperone HSPB1 and, interestingly, an immunoproteasome-specific subunit PSMB9. Moreover, PSMB9 expression is dependent on the translation elongation factor EEF1A2. These mechanisms constitute a defense response to preserve cellular proteostasis under mitochondrial stress. Our findings define a mode of proteasomal activation through the change in proteasome composition driven by EEF1A2 and its spatial regulation, and are useful to formulate therapies to prevent neurodegenerative diseases.

This paper introduces design and simulation of a low cost shunt active power filter, which allows dynamic power factor correction and harmonic compensation for a nonlinear load. One of the most important features of the shunt active filter system proposed is its versatility over a variety of different conditions. The active filter controller is based on the Instantaneous power theory p q theory , which monitors the load current and injects equal amplitude and opposite phase compensation currents to neutralise load current harmonics. The application of the positive sequence voltage detector from within the active filter controller is the key component of the system. The positive sequence voltage detector gives incredible versatility to the application of the active filter, because it can be installed and compensate for load current harmonics even when the input voltage is highly distorted and unbalanced. The controller algorithm is carried out using MATLAB Simulink. Dr. G. Madasamy "Simulation of Shunt Active Power Filter Based on p-q Theory" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-1 , February 2023, URL: https://www.ijtsrd.com/papers/ijtsrd52791.pdf Paper URL: https://www.ijtsrd.com/engineering/electrical-engineering/52791/simulation-of-shunt-active-power-filter-based-on-pq-theory/dr-g-madasamy

The objective of active power factor correction is to make the input to a power supply look like a simple resistor. An active power factor corrector does this by programming the input current in response to the input voltage. As long as the ratio between the voltage and current is a constant the input will be resistive and the power factor will be unity. When the ratio deviates from a constant, the input will contain phase displacement, harmonic distortion or both and either one will degrade the power factor. The most common definition of power factor is the ratio of real power to apparent power. A boost regulator is an excellent choice for the power stage of an active power factor corrector, because the input current is continuous and this produces the lowest level of conducted noise and the best input current waveform. The boost regulator input current must be forced or programmed to be proportional to the input voltage waveform for power factor correction. Feedback is necessary to control the input current and either peak current mode control or average current mode control may be used. Both techniques may be implemented with the UC3854. Dr. G. Madasamy "Simulation of Single Phase Active Power Factor Pre-Regulator" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-7 , December 2022, URL: https://www.ijtsrd.com/papers/ijtsrd52594.pdf Paper URL: https://www.ijtsrd.com/engineering/electrical-engineering/52594/simulation-of-single-phase-active-power-factor-preregulator/dr-g-madasamy

An immunohistochemical study of astrocytomas of neuroepithelial tumors, which differ from each other in terms of their degree of malignancy, was conducted using the following monoclonal antibodies: VGFR (vascular endothelial growth factor), Ki67 (proliferation marker), Bcl 2 (antiapoptotic factor), p53- (suppressor protein) and glial. immunohistochemical characteristics were analyzed in astrocytomas.

Accreditation by a reputable organization, such as the National Commission for Academic Accreditation and Assessment (NCAAA) or the Accreditation Board for Engineering and Technology (ABET), is a requirement for academic institutions to provide superior educational services. The challenge of quality improvement (QI) in education is still very real. Effective quality procedures in academic institutions depend on a number of quality factors, including work satisfaction and effective communication. Positive academic satisfaction and strong communication skills will not only improve the working atmosphere and boost productivity, but they will also increase job satisfaction. This quantitative research study's objectives are to examine organizational communication, define communication styles, and gauge work satisfaction at an engineering college. An online survey that is based on a questionnaire is used to gather information about job satisfaction. The perceptions of the respondents were gauged using five-point Likert-type scales. The scope of the study encompassed the entire population, or the entire academic staff employed by the college. The academic staff is divided into groups using factor analysis, which subsequently identifies a number of intriguing QI topics. The findings of this study also provide credence to the idea that academic staff members who have supportive leaders, good working conditions, and a maximized feeling of perceived job security exhibit much better levels of general academic job satisfaction. The authors feel that the same methodologies and assessments can be utilized in any kind of study, even if this case is focused on a single college of engineering.

Evolutionary algorithms (EAs) have the potential to handle complex, multi-dimensional optimization problems in the field of phased array. Out of different EAs, particle swarm optimization (PSO) is a popular choice. In a phased array, antenna element failure is a common phenomenon and this leads to degradation of the array factor (AF) pattern, primarily in terms of increased side lobe levels (SLLs), displacement of nulls and reduction in the null depths. The recovery of a degraded pattern using a cost and time-effective approach is on demand. In this context, an attempt made to obtain an optimized AF pattern after fault in a 49 elements quasi-circular aperture equilateral triangular grid active planar phased array using PSO. In the paper, multiple cases on recovery are discussed having a maximum 20% element failure. Each recovery is also further evaluated by different statistical analyses. A dedicated software tool was developed to carry out the work presented in this paper.

The universally conserved P-loop ATPase Ola1 is implicated in various cellular stress response pathways, as well as in cancer and tumor progression. However, Ola1p functions are divergent between species, and the involved mechanisms are only poorly understood. Here, we studied the role of Ola1p in the heat shock response of the yeast Saccharomyces cerevisiae using a combination of quantitative and pulse labeling-based proteomics approaches, in~vitro studies, and cell-based assays. Our data show that when heat stress is applied to cells lacking Ola1p, the expression of stress-protective proteins is enhanced. During heat stress Ola1p associates with detergent-resistant protein aggregates and rapidly forms assemblies that localize to stress granules. The assembly of Ola1p was also observed in~vitro using purified protein and conditions, which resembled those in living cells. We show that loss of Ola1p results in increased protein ubiquitination of detergent-insoluble aggregates recovered from heat-shocked cells. When cells lacking Ola1p were subsequently relieved from heat stress, reinitiation of translation was delayed, whereas, at the same time, de novo synthesis of central factors required for protein refolding and the clearance of aggregates was enhanced when compared with wild-type cells. The combined data suggest that upon acute heat stress, Ola1p is involved in the stabilization of misfolded proteins, which become sequestered in cytoplasmic stress granules. This function of Ola1p enables cells to resume translation in a timely manner as soon as heat stress is relieved.

Most plants grow and develop by taking up nutrients from the soil while continuously under threat from foraging animals. Carnivorous plants have turned the tables by capturing and consuming nutrient-rich animal prey, enabling them to thrive in nutrient-poor soil. To better understand the evolution of botanical carnivory, we compared the draft genome of the Venus flytrap (Dionaea muscipula) with that of its aquatic sister, the waterwheel plant Aldrovanda vesiculosa, and the sundew Drosera spatulata. We identified an early whole-genome duplication in the family as source for carnivory-associated genes. Recruitment of genes to the trap from the root especially was a major mechanism in the evolution of carnivory, supported by family-specific duplications. Still, these genomes belong to the gene poorest land plants sequenced thus far, suggesting reduction of selective pressure on different processes, including non-carnivorous nutrient acquisition. Our results show how non-carnivorous plants evolved into the most skillful green hunters on the planet.

Plants adapt to the environment by either long-term genome evolution or by acclimatization processes where the cellular processes and metabolism of the plant are adjusted within the existing potential in the genome. Here we studied the adaptation strategies in date palm, Phoenix dactylifera, under mild heat, drought and combined heat and drought by transcriptomic and metabolomic profiling. In transcriptomics data, combined heat and drought resembled heat response, whereas in metabolomics data it was more similar to drought. In both conditions, soluble carbohydrates, such as fucose, and glucose derivatives, were increased, suggesting a switch to carbohydrate metabolism and cell wall biogenesis. This result is consistent with the evidence from transcriptomics and cis-motif analysis. In addition, transcriptomics data showed transcriptional activation of genes related to reactive oxygen species in all three conditions (drought, heat, and combined heat and drought), suggesting increased activity of enzymatic antioxidant systems in cytosol, chloroplast and peroxisome. Finally, the genes that were differentially expressed in heat and combined heat and drought stresses were significantly enriched for circadian and diurnal rhythm motifs, suggesting new stress avoidance strategies.

Evolutionary algorithms (EAs) have the potential to handle complex, multi-dimensional optimization problems in the field of phased array. Out of different EAs, particle swarm optimization (PSO) is a popular choice. In a phased array, antenna element failure is a common phenomenon and this leads to degradation of the array factor (AF) pattern, primarily in terms of increased side lobe levels (SLLs), displacement of nulls and reduction in the null depths. The recovery of a degraded pattern using a cost and time-effective approach is on demand. In this context, an attempt made to obtain an optimized AF pattern after fault in a 49 elements quasi-circular aperture equilateral triangular grid active planar phased array using PSO. In the paper, multiple cases on recovery are discussed having a maximum 20% element failure. Each recovery is also further evaluated by different statistical analyses. A dedicated software tool was developed to carry out the work presented in this paper.

Mitochondrial translation in the parasitic protozoan Trypanosoma brucei relies on imported eukaryotic-type tRNAs as well as on bacterial-type ribosomes that have the shortest known rRNAs. Here we have identified the mitochondrial translation elongation factors EF-Tu, EF-Ts, EF-G1 and release factor RF1 of trypanosomatids and show that their ablation impairs growth and oxidative phosphorylation. In vivo labelling experiments and a SILAC-based analysis of the global proteomic changes induced by EF-Tu RNAi directly link EF-Tu to mitochondrial translation. Moreover, EF-Tu RNAi reveals downregulation of many nuclear encoded subunits of cytochrome oxidase as well as of components of the bc1-complex, whereas most cytosolic ribosomal proteins were upregulated. Interestingly, T.bruceiEF-Tu has a 30-amino-acid-long, highly charged subdomain, which is unique to trypanosomatids. A combination of RNAi and complementation experiments shows that this subdomain is essential for EF-Tu function, but that it can be replaced by a similar sequence found in eukaryotic EF-1a, the cytosolic counterpart of EF-Tu. A recent cryo-electron microscopy study revealed that trypanosomatid mitochondrial ribosomes have a unique intersubunit space that likely harbours the EF-Tu binding site. These findings suggest that the trypanosomatid-specific EF-Tu subdomain serves as an adaption for binding to these unusual mitochondrial ribosomes.

BACKGROUND: Functional loss of the tumor suppressor Smad4 is involved in pancreatic and colorectal carcinogenesis and has been associated with the acquisition of invasiveness. We have previously demonstrated that the heterotrimeric basement membrane protein laminin-332 is a Smad4 target. Namely, Smad4 functions as a positive transcriptional regulator of all three genes encoding laminin-332; its loss is thus implicated in the reduced or discontinuous deposition of the heterotrimeric basement membrane molecule as evident in carcinomas. Uncoupled expression of laminin genes, on the other hand, namely overexpression of the laminin-gamma2 chain is an impressive marker at invasive edges of carcinomas where tumor cells are maximally exposed to signals from stromal cell types like macrophages. As Smad4 is characterized as an integrator of multiple extracellular stimuli in a strongly contextual manner, we asked if loss of Smad4 may also be involved in uncoupled expression of laminin genes in response to altered environmental stimuli. Here, we address Smad4 dependent effects of the prominent inflammatory cytokine TNFalpha on tumor cells. RESULTS: Smad4-reconstituted colon carcinoma cells like adenoma cells respond to TNFalpha with an increased expression of all three chains encoding laminin-332; coincubation with TGFbeta and TNFalpha leads to synergistic induction and to the secretion of large amounts of the heterotrimer. In contrast, in Smad4-deficient cells TNFalpha can induce expression of the gamma2 and beta3 but not the alpha3 chain. Surprisingly, this uncoupled induction of laminin-332 chains in Smad4-negative cells rather than causing intracellular accumulation is followed by the release of gamma2 into the medium, either in a monomeric form or in complexes with as yet unknown proteins. Soluble gamma2 is associated with increased cell migration. CONCLUSIONS: Loss of Smad4 may lead to uncoupled induction of laminin-gamma2 in response to TNFalpha and may therefore represent one of the mechanisms which underlie accumulation of laminin-gamma2 at the invasive margin of a tumor. The finding, that gamma2 is secreted from tumor cells in significant amounts and is associated with increased cell migration may pave the way for further investigation to better understand its functional relevance for tumor progression.