The Role of Atropine Eye Drops in Myopia Control

Siriraj Medical Journal, 2023

Journal of Clinical Medicine

Myopia is the most common ocular disorder worldwide with an increasing prevalence over the past few decades. It is a refractive error associated with excessive growth of the eyeball. Individuals with myopia, especially high myopia, are prone to develop sight-threatening complications. Currently, atropine is the only drug that is used to slow myopia progression in clinical practice. However, there are still areas of uncertainty such as treatment strategy, optimal concentration when considering risk–benefit ratio and active treatment period. Since the prevalence of myopia is much higher in Asian countries, most of the research on myopia control has been conducted in Asia. Data on the efficacy and tolerability to atropine eye drops in the non-Asian population remains limited. In this review, we summarize the results of published clinical trials on the effectiveness and tolerability of atropine eye drops for myopia control in non-Asian regions. The efficacy was evaluated by the mean cha...

Ophthalmology and Therapy, 2019

Beyoğlu eye journal, 2022

Journal of Clinical Medicine

Myopia will affect half the global population by 2050 and is a leading cause of vision impairment. High-dose atropine slows myopia progression but with undesirable side-effects. Low-dose atropine is an alternative. We report the effects of 0.01% or 0.005% atropine eye drops on myopia progression in 13 Australian children aged between 2 and 18 years and observed for 2 years without and up to 5 years (mean 2.8 years) with treatment. Prior to treatment, myopia progression was either ‘slow’ (more positive than −0.5 D/year; mean −0.19 D/year) or ‘fast’ (more negative than −0.5 D/year; mean −1.01 D/year). Atropine reduced myopic progression rates (slow: −0.07 D/year, fast: −0.25 D/year, combined: before: −0.74, during: −0.18 D/year, p = 0.03). Rebound occurred in 3/4 eyes that ceased atropine. Atropine halved axial growth in the ‘Slow’ group relative to an age-matched model of untreated myopes (0.098 vs. 0.196 mm/year, p < 0.001) but was double that in emmetropes (0.051 mm/year, p <...

Pakistan Armed Forces Medical Journal, 2020

Objective: To determine the effect of atropine eye drop 0.01% on myopia progression in high and low myopes. Study Design: Quasi experimental study. Place and Duration of study: Armed Forces Institute of Ophthalmology (AFIO) Rawalpindi, Pakistan from Mar 2017 to Jul 2018. Methodology: A total of 72 eyes of 36 patients successfully completed the follow up. Age ranging from 5 to 15 years, refractive error from 2.0D to 20D was considered and grouped into high and low myope on the basis of refractive error and axial length (AL). Those with other ocular disease were excluded. Increase in Axial Lenght of 0.5mm or refractive error 0.5D in 3 months were started 0.01% atropine eye drop in both eyes. Follow up was 3 monthly, final readings of axial length and spherical equivalent (SE) were noted at 12 months of treatment initiation. Results: The mean spherical equivalent and axial length in group high myopes was 12.40D ± 3.55 and 27.28 ± 1.19mm respectively while in group low myopes was 4.99D ...

Ophthalmology, 2009

Ophthalmology, 2012

2019

Bruce A. Van Orden and Brent L. Top, eds., Doctrines of the Book of Mormon: The 1991 Sperry Symposium. Salt Lake City: Deseret Book, 1992. viii + 262 pp., with subject index. $14.95. Reviewed by Mack C. Stirling This book consists of eighteen chapters based on papers read at the twentieth annual Sidney B. Sperry Symposium on October 26, 1991. All of the contributors were members of the Brigham Young University religious education faculty except John Welch (Professor of Law at Brigham Young University), Gerald W. Lund (employed by the Church Educational System), and Elder Robert E. Wells of the First Quorum of the Seventy. Prior to publication each paper underwent two reviews, one by a member of the religion faculty and one by a member of another B YU department. The editors state in the preface to the book that the purpose of the symposium was to teach "sound doctrine" from the Book of Mormon. It was hoped as well that the essays in the book would prove of particular use t...

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