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2004, Molecular Psychiatry
Journal of Neurochemistry
The effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome2011 •
Biological Psychiatry
Deficient Hippocampal Neuron Expression of Proteasome, Ubiquitin, and Mitochondrial Genes in Multiple Schizophrenia Cohorts2005 •
Human Molecular Genetics
RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity2006 •
International journal of biological sciences
Dysregulated mitochondrial genes and networks with drug targets in postmortem brain of patients with posttraumatic stress disorder (PTSD) revealed by human mitochondria-focused cDNA microarrays2008 •
Posttraumatic stress disorder (PTSD) is associated with decreased activity in the dorsolateral prefrontal cortex (DLPFC), the brain region that regulates working memory and preparation and selection of fear responses. We investigated gene expression profiles in DLPFC Brodmann area (BA) 46 of postmortem patients with (n=6) and without PTSD (n=6) using human mitochondria-focused cDNA microarrays. Our study revealed PTSD-specific expression fingerprints of 800 informative mitochondria-focused genes across all of these 12 BA46 samples, and 119 (+/->1.25, p<0.05) and 42 (+/->1.60, p<0.05) dysregulated genes between the PTSD and control samples. Quantitative RT-PCR validated the microarray results. These fingerprints can essentially distinguish the PTSD DLPFC BA46 brains from controls. Of the 119 dysregulated genes (+/-> or =125%, p<0.05), the highest percentages were associated with mitochondrial dysfunction (4.8%, p=6.61 x 10(-6)), oxidative phosphorylation (3.8%, p=9....
Molecular Psychiatry
Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders2002 •
2005 •
PLoS Currents
Effect of enhanced voluntary physical exercise on brain levels of monoamines in Huntington disease mice2011 •
2012 •
Frontiers in behavioral neuroscience
Analysis of kinase gene expression in the frontal cortex of suicide victims: implications of fear and stress2011 •
Suicide is a serious public health issue that results from an interaction between multiple risk factors including individual vulnerabilities to complex feelings of hopelessness, fear, and stress. Although kinase genes have been implicated in fear and stress, including the consolidation and extinction of fearful memories, expression profiles of those genes in the brain of suicide victims are less clear. Using gene expression microarray data from the Online Stanley Genomics Database and a quantitative PCR, we investigated the expression profiles of multiple kinase genes including the calcium calmodulin-dependent kinase (CAMK), the cyclin-dependent kinase, the mitogen-activated protein kinase (MAPK), and the protein kinase C (PKC) in the prefrontal cortex (PFC) of mood disorder patients died with suicide (N = 45) and without suicide (N = 38). We also investigated the expression pattern of the same genes in the PFC of developing humans ranging in age from birth to 49 year (N = 46). The ...
Rationale The implications of the neurosteroid 3α-hydroxy- 5α-pregnan-20-one [allopregnanolone (Allo)] in neuropsychiatric disorders have been highlighted in several recent clinical investigations. For instance, Allo levels are decreased in the cerebrospinal fluid (CSF) of patients with posttraumatic stress disorder (PTSD) and major unipolar depression. Neurosteroidogenic antidepressants [i.e., selective brain steroidogenic stimulants (SBSSs)], including fluoxetine and analogs, correct this decrease in a manner that correlates with improved depressive symptoms. Allo positively and allosterically modulatesGABAaction at postsynaptic and extrasynaptic GABAA receptors. It is synthesized in both the human and rodent brain cortices by principal glutamatergic pyramidal neurons from progesterone by the sequential action of 5α-reductase type I (5α-RI), which is the rate-limiting step enzyme in Allo biosynthesis, and 3α-hydroxysteroid dehydrogenase (3α- HSD), which converts 5α-dehydroprogesterone into Allo. Hypothesis We thus hypothesized that decreased CSF levels of Allo in depressed patients could reflect a brain dysfunction of 5α-RI. Methods In a pilot study of samples from six patients per group [six depressed patients and six nonpsychiatric subjects (NPS)], we studied the expression of 5α-RI messenger RNA (mRNA) in prefrontal cortex Brodmann’s area 9 (BA9) and cerebellum from depressed patients obtained from the Maryland Brain Collection at the Maryland Psychiatric Research Center (Baltimore, MD) that were age-matched with NPS. Results The levels of 5α-RI mRNAwere decreased from 25± 5.8 in NPS to 9.1±3.1 fmol/pmol neuronal specific enolase (NSE) (t1,10=2.7, P=0.02) in depressed patients. These differences are absent in the cerebellum of the same patients. The levels of neurosteroids were determined in the prefrontal cortex BA9 of depressed patients obtained from the Stanley Foundation Brain BankNeuropathology Consortium, Bethesda (MD). The BA9 levels of Allo in male depressed patients failed to reach statistical difference from the levels of NPS (1.63±1.01 pg/mg, n=8, in NPS and 0.82±0.33 pg/mg, n=5, in nontreated depressed patients). However, depressed patients who had received antidepressant treatment (three patients SSRI and one TCA) exhibited increased BA9 Allo levels (6.16±2.5 pg/mg, n=4, t1,9=2.4, P=0.047) when compared with nontreated depressed patients. Conclusions Although in a small number of patients, this finding is in-line with previous reports in the field that have observed an increase of Allo levels in CSF and plasma of depressed patients following antidepressant treatment. Hence, the molecular mechanisms underlying major depression may include a GABAergic neurotransmission deficit caused by a brain Allo biosynthesis downregulation, which can be normalized by SBSSs.
Molecular Psychiatry
Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia2002 •
Neuropsychopharmacology
Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide2010 •
Neuropharmacology
Chronic valproate treatment blocks D2-like receptor-mediated brain signaling via arachidonic acid in rats2011 •
Experimental neurology
GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury2015 •
Journal of Affective Disorders
Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder2008 •
Biological Psychiatry
Alterations in cell adhesion molecule L1 and functionally related genes in major depression: A postmortem study2005 •
Molecular Psychiatry
Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder2009 •
Journal of Psychiatric Research
Altered fatty acid concentrations in prefrontal cortex of schizophrenic patients2013 •
Schizophrenia Research
Borna disease virus antibodies and the deficit syndrome of schizophrenia1997 •
Psychopharmacology
5-HT 2A/2C receptor signaling via phospholipase A 2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter2005 •
Current topics in behavioral neurosciences
Strategies for the development of animal models for bipolar disorder: new opportunities and new challenges2011 •
Schizophrenia Research
Schizophrenia and bipolar disorder show both common and distinct changes in cortical interneuron markers2014 •
1999 •
Neuropsychopharmacology
Chronic Lithium Chloride Administration Attenuates Brain NMDA Receptor-Initiated Signaling via Arachidonic Acid in Unanesthetized Rats2006 •
Journal of Psychiatric Research
Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains2009 •
Learning & Memory
Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice2011 •
Psychiatry Research: Neuroimaging
The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults2007 •
2009 •
The lancet. Psychiatry
Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis2017 •
Archives of General Psychiatry
Human Dysbindin (DTNBP1) Gene Expression inNormal Brain and in Schizophrenic Prefrontal Cortex and Midbrain2004 •
NeuroRX
Neural circuitry and neuroplasticity in mood disorders: Insights for novel therapeutic targets2006 •
2014 •
Molecular Psychiatry
A novel Alzheimer disease locus located near the gene encoding tau protein2015 •
Schizophrenia Research
Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients2008 •
American Journal of Medical Genetics
Is theWKL1 gene associated with schizophrenia?2004 •
Neuroscience Letters
Autoradiographic localization of mouse brain adenosine receptors with an antagonist ([3H]xanthine amine congener) ligand probe1988 •
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Transient postnatal fluoxetine leads to decreased brain arachidonic acid metabolism and cytochrome P450 4A in adult mice2014 •
Molecular Brain Research
Hippocampal NMDA receptor subunit expression and watermaze learning in estrogen deficient female mice2005 •
European Journal of Neuroscience
Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation2003 •
Journal of Neurochemistry
Alternative splicing of human metabotropic glutamate receptor 32006 •
Molecular Psychiatry
Investigating neural primacy in Major Depressive Disorder: multivariate Granger causality analysis of resting-state fMRI time-series data2011 •
Dialogues in clinical neuroscience
DNA methylation and demethylation as targets for antipsychotic therapy2014 •
Molecular Psychiatry
Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems2013 •
… International Journal of …
AR-A014418, a Selective GSK-3 Inhibitor, Produces Antidepressant-Like Effects In the Forced Swim Test2004 •