NEUROSCIENCE
Published: 06 June 2016
doi: 10.3389/frym.2016.00007
Oxytocin: How Does This Neuropeptide
Change Our Social Behavior?
Daniel S. Quintana1* and Gail A. Alvares2,3
1
Division of Mental Health and Addiction, NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, University
of Oslo, Oslo, Norway, 2Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia, 3Cooperative Research
Centre for Living with Autism (Autism CRC), Brisbane, QLD, Australia
reviewed by:
St. Bernard
Regional
Catholic
School
10–13 years old
Neuropeptide
A small molecule
naturally produced in the
body that acts a
messenger to trigger
responses in our body,
such as the feeling of
hunger.
Oxytocin
A neuropeptide (see
above) that is known to
inluence how we behave
around other people.
Neuropeptides are small molecules that act as messengers between different
brain regions. There are roughly 100 neuropeptides that are important for
various functions, including hunger, memory, and learning. Oxytocin is a
neuropeptide that plays a crucial role in childbirth and breastfeeding. More
recently, oxytocin has been shown to be essential for our social behaviors.
When given to people in the form of a nasal spray, oxytocin can change key
aspects of social behavior, such as how easily we can recognize emotions
in others. People with autism often have dificulties in understanding and
using social information, and scientists have been testing oxytocin nasal
spray as a potential treatment. But how does oxytocin nasal spray travel
from the nose to the brain, and how does it change how we behave socially?
Neuropeptides are small molecules that act as messengers between diferent brain regions. here are roughly 100 neuropeptides that control various
functions, including hunger, memory, and learning. Oxytocin is a neuropeptide that plays a crucial role in childbirth and breastfeeding. Oxytocin is
produced in the hypothalamus, an almond-sized structure near the base of
our brain. Ater production, oxytocin moves from the hypothalamus to the
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Oxytocin and Social Behavior
rest of the brain, and throughout the body by way of the nearby pituitary
gland (Figure 1).
here are millions of oxytocin receptors in the human body. hese tiny receptors are like locks, and oxytocin is the key. When oxytocin unlocks the oxytocin
receptors, these receptors become activated and trigger speciic responses in
the body. For example, during childbirth, the body releases a huge amount of
oxytocin, which activates oxytocin receptors located on the mother’s uterus
(an organ located in the abdomen where the baby develops before birth).
hese receptors signal contraction of the uterus, which assists the baby’s trip
through the birth canal during birth. Later on, when a baby breastfeeds, oxytocin is released from the mother’s brain to stimulate the low of breast milk.
If mothers are having diiculty in delivering the baby or with breastfeeding,
their doctors will sometimes prescribe oxytocin (an artiicial version that is
sometimes delivered via a nasal spray) to help them with these processes.
However, oxytocin does not just act in females – it is also involved in the
control of blood pressure and kidney functions in both males and females.
Figure 1
Oxytocin is naturally
produced in a part of the
brain called the
hypothalamus and
distributed both within the
brain and to the rest of the
body by way of the
pituitary gland.
Artiicial oxytocin nasal
spray is thought to access
the brain directly
through the nerves
located inside the nasal
cavity that are linked to
the brain. Artiicial
oxytocin nasal spray has
been shown to affect
activity in different parts of
the brain, such as the
prefrontal cortex,
amygdala, and the brain
stem. The blood–brain
barrier acts like a
protective ilter for the
brain by preventing
unwanted molecules
entering the brain from the
blood stream, but it can
also prevent the entrance
of large drug molecules,
such as oxytocin. Small
amounts of the oxytocin
nasal spray are sometimes
swallowed, which is
relatively harmless.
Image adapted from
Quintana et al. [1].
WHAT IS THE ROLE OF OXYTOCIN IN SOCIAL
BEHAVIOR?
Although the breastfeeding and birthing efects of oxytocin have been known
for sometime, more recent research has shown that the oxytocin system is also
Figure 1
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Quintana and Alvares
social behavior
How we behave and
interact with other
people. This includes
how we behave around
one person (e.g., a friend
or romantic partner) or a
group of people (e.g., a
class of children or a
family).
prairie voles
A small mammal about
the size of a mouse.
Males and females
typically stay together to
raise their young, which
is rare for animals.
Oxytocin and Social Behavior
important for how mammals develop and maintain complex interactions with
other individuals (e.g., romantic relationships). hese types of interactions are
called social behaviors. he irst clues for oxytocin’s social role were shown
with the help of animal research in 1970s and 1980s. Female rats do not pay
much attention to rat pups that are not their own. However, giving oxytocin to
female rats that have never had their own pups leads to an interesting reversal
of this behavior. hese female rats show mother-like behaviors, such as licking
and nest building, toward pups that are not their own. Later, scientists turned
their attention to prairie voles. hese small mouse-like mammals are one of
the few species (including humans) in which the male and female parents typically stay together to raise their young. Using powerful microscopes, scientists
have shown that the brains of prairie voles have a large number of oxytocin
receptors, especially within brain areas that are involved in social behavior.
Further research has also shown that these brain regions are important for
pair bonding, which is a term used to refer to how male and female animals
oten pair up to create and raise their children. However, the closely related
meadow vole (Figure 2), which lives mostly alone, does not have as many
oxytocin receptors in these social brain regions. In fact, blocking the efects of
oxytocin in prairie voles reverses these pair bonding behaviors, demonstrating how important this neuropeptide is for social behavior [2]. Oxytocin (or
closely related neuropeptides) has also been found to regulate social behaviors
in various animals such as ish, birds, and snails.
WHAT ARE THE EFFECTS OF OXYTOCIN IN HUMANS
AND HOW DOES IT WORK?
Ater seeing the efects of oxytocin on social behavior in mammals, researchers
began to investigate whether these efects could also be observed in humans.
At the same time, other research discovered that people with conditions that
involve diiculties in social behavior (for example, problems in making friends
Figure 2
The meadow vole (shown
here) and the closely
related prairie vole (not
shown) have been studied
to learn more about social
behavior in humans.
Figure from Wikimedia
Commons. https://
commons.wikimedia.org/
wiki/File:Baby_meadow_
vole.jpg
Figure 2
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Oxytocin and Social Behavior
or forming romantic relationships) have lower levels of oxytocin in their blood
compared with people without these conditions. Based on these results and
the earlier animal research, scientists began to examine the efect of giving
oxytocin to humans as a nasal spray. It was hoped that giving oxytocin as a
medication might improve some social behaviors in people who have diiculties in these areas.
An important part of social behavior is understanding what other people
are thinking or feeling. his ability is also known as “theory of mind,” as it
involves making sense of what is going on inside someone else’s head. If we
can understand others’ thoughts or beliefs, and how this might be diferent
from our own thoughts or beliefs, then we can better predict how we should
interact with them or how they will behave in the future. Some of this information is transmitted without words, through body language. For example,
we sometimes see sad people slump their shoulders forward. However, most
emotional information comes from the face, particularly from the eye and
mouth regions. For example, just from looking at the boy in Figure 3D, most
people would view his smile and think that he is happy. he same boy in
Figure 3E would be seen as angry due to his narrowed lips and his eyebrows
being pulled down together. Most people can very easily and quickly understand the various types of emotional information shown in Figure 3. However,
this skill can be limited or absent in some people.
To test if oxytocin improves the ability to understand emotional information,
researchers gave adults oxytocin and then measured how they performed on
a theory of mind test. his test presented photographs of the eye regions of
diferent people and asked the participants to guess what each person was
thinking or feeling. Ater taking oxytocin, compared to a control nasal spray
that did not contain any oxytocin, people performed better on this theory
of mind test [3]. Later research showed that this improvement is related to
changes in the parts of the brain that are important for processing of social
information. hese regions have very high numbers of oxytocin receptors.
Figure 3
Most emotional
information is broadcast
from our faces.
This boy is displaying
various facial emotions;
A. neutral/no emotion,
B. afraid, C. sad,
D. happy, and E. angry.
Figures from the NIMH
Child Emotional Faces
Picture Set (NIMH-ChEFS)
http://devepi.duhs.duke.
edu/NIMH_Pictures.html
Although understanding these emotional clues from the eye region is important, people irst need to pay attention to the eye region in order to even get
this information. Many individuals who have diiculties in understanding
emotions also spend less time looking at faces, particularly their eyes. By using
Figure 3
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Oxytocin and Social Behavior
special cameras called eyetrackers that record exactly where people are looking
(Figure 4), researchers tested which areas of the face people looked at the most
ater taking oxytocin [4]. hey found that oxytocin increases the amount of
time people spend looking at the eye region of these faces and decreases the
time spent looking other regions of the face. Along with these efects, oxytocin
has also been shown to change our social behavior. For instance, researchers
discovered that giving people oxytocin increases loyalty toward their friends
and families.
Figure 4
By using special cameras,
eyetracker machines can
record exactly where
people are looking when
they look at faces on a
computer screen.
A “heat map” can be
constructed to visualize
where people spend the
most time looking, with
the “hotter” areas
receiving the most
attention. The “before”
face image on the left is
represents the average
eye gaze from a group of
people with ASC before
they were given oxytocin
nasal spray, with little time
spent looking at the eyes
and more time toward
other face areas. The
“after” face image on the
right shows the increased
gaze to the eye region
that has been reported
after people with ASC are
given oxytocin nasal
spray. Adapted igures
from the NIMH-ChEFS
http://devepi.duhs.duke.
edu/NIMH_Pictures.html
However, the efects of oxytocin are not all positive. Since this early research,
scientists have learned that oxytocin inluences both positive and negative
emotions. For example, oxytocin administration has been shown to increase
negative emotions, such as envy/jealousy, and the pleasure we get from witnessing the diiculties of others. Along with increasing cooperation with people in our own social group, oxytocin also decreases cooperation with those
outside our social groups. So, rather than only being involved in “positive”
social behaviors, oxytocin is more accurately described simply as a “social”
hormone, responsible for many types of social behaviors, both positive and
negative. here are two main ways that oxytocin is thought to efect our social
behavior and understanding of social situations. he irst way is by increasing
how much we notice social clues around us, either positive or negative. he
second is by increasing our desire to approach and interact with other people.
WHY USE A NASAL SPRAY TO DELIVER MEDICATION
TO THE BRAIN?
Unlike most other medications, oxytocin is usually administered as a liquid
spray into the nose. his medication is an artiicial form of oxytocin that acts
like the oxytocin naturally produced by the body. Medications targeted to the
brain, such as antidepressants, are typically swallowed as a tablet or a liquid.
Figure 4
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Quintana and Alvares
blood–brain
barrier (BBB)
A protective ilter that
prevents unwanted
molecules from entering
the brain, which could
make us unwell.
Oxytocin and Social Behavior
his usually works well, as small drug molecules can get into the bloodstream
through the intestines and then slip through the barrier between the bloodstream and the brain. his barrier that surrounds the brain, also known as the
blood–brain barrier (BBB), acts like a protective ilter by preventing unwanted
molecules from entering the brain, but it can also prevent the entrance of large
drug molecules, such as oxytocin. his means that oxytocin will never reach
the brain by swallowing it as a liquid. Researchers sometimes inject oxytocin
directly into the brain in studies using small mammals; however, this is not a
good solution in humans, so other methods are needed.
he nose provides an efective route for medication delivery to the brain. he
surface on the inside of our noses is an easily reachable area of the body that
has a direct connection to the brain through a set of nerves (Figure 1). By
spraying liquid medication into the nose, medications potentially avoid the
BBB altogether. However, this spray needs to travel deep inside your nose –
much deeper than your inger can reach – to reach the nasal regions that are
linked to the brain.
Research has shown that the level of oxytocin in brain luid increases ater a
person receives an oxytocin nasal spray. Although some side-efects have been
reported (e.g., increased thirst), these are typically uncommon. Oxytocin nasal
spray that does not reach the brain can also enter the bloodstream, although
only very small amounts of oxytocin circulating in blood may actually cross
the BBB into the brain. herefore, the nose provides the easiest and safest way
to get medications, such as oxytocin, to the brain.
OXYTOCIN AS A TREATMENT?
autism
spectrum
conditions
(ASC)
A group of complex
conditions where people
can have dificulties in
forming relationships and
communicating with
others. These
communication
dificulties often include
problems making eye
contact or understanding
other people’s emotions.
Repetitive behaviors
(such as lining toy cars
up in a row repeatedly)
or particular interests in
very speciic topics are
also commonly seen in
people with an autism
spectrum condition.
Some conditions, such as autism spectrum conditions (ASC), are associated
with poor social functioning. People who have ASC may experience diiculties in forming or maintaining relationships, can have trouble making eye
contact, and may also have some repetitive behaviors (for example, lining toy
cars up in a row repeatedly) or particular interests in very speciic topics. It is
important to note that autism is considered a “spectrum” condition, meaning
that not all people with this condition are the same and that some symptoms
can be more or less severe in any one person. For instance, people with ASC
can have various intellectual abilities and can have many strengths in various
aspects of their lives. However, many people with ASC experience signiicant
diiculties with social behaviors, making it diicult to go to school, work, or
have relationships. Unfortunately, there are currently no efective medications
available to help with these social diiculties. Research in this area is still going
on; however, some scientists have shown that when a single dose of oxytocin
nasal spray is given to people with ASC, it can increase the amount of time
they spend looking at other people’s eyes and their ability to recognize emotions correctly.
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Although seeing improvement in speciic social behaviors inside a laboratory
is an important irst step, research also needs to demonstrate that oxytocin
nasal spray can improve day-to-day social functioning in the real world, with
long-term daily use. Early research has shown that taking oxytocin nasal spray
over 5 weeks led to small improvements in social behavior in young children
with ASC [5]. However, other research in older children and adults with ASC
has not shown any improvements ater similar periods of taking oxytocin.
So, it is still unclear whether oxytocin can actually help people with ASC by
improving their social behaviors.
WHAT ELSE DO WE STILL NEED TO LEARN ABOUT
OXYTOCIN NASAL SPRAY?
he fact that diferent studies have given diferent results tells us that we still
have a lot to learn about how oxytocin inluences behavior in humans. For
example, the most efective nasal spray dose to use is still not known. In fact,
we have found that a smaller dose may be more helpful than a larger dose [6]
– bigger may not be better! Scientists are also still discovering exactly how oxytocin given through the nose might travel to the brain. he way that oxytocin
is sprayed up the nose also inluences its efects. he most commonly used
nasal spray devices may not be the best method to deliver oxytocin, and new
types of sprays that are better for delivering oxytocin to the brain are currently
being tested [6]. Overall, it is clear that more work is needed to understand all
the factors that inluence the response to nasally delivered oxytocin.
CONCLUSION
Oxytocin plays an important role in social behavior and in the way we understand our social world. However, more research is needed before oxytocin
can be used as a treatment for ASC, since scientists still do not have a clear
understanding of how oxytocin works. Universities and hospitals around the
world, including ours in Australia and Norway, are continuing to test the
efectiveness of oxytocin on improving social behavior. his work will hopefully lead us to understand whether or not this hormone can help people with
conditions like ASC at their school or workplaces and improve their relationships with other people.
AUTHOR CONTRIBUTIONS
DQ and GA conceived the manuscript idea. DQ drated the work and GA
revised it critically for important intellectual content. DQ and GA gave inal
approval of the version to be published and agree to be accountable for all
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aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
ORIGINAL source article
Quintana, D. S., Alvares, G. A., Hickie, I. B., and Guastella, A. J. 2015. Do delivery routes
of intranasally administered oxytocin account for observed effects on social cognition
and behavior? A two-level model. Neurosci. Biobehav. Rev. 49:182–192.
doi:10.1016/j.neubiorev.2014.12.011
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Quintana, D. S., Westlye, L. T., Rustan, O. G., Tesli, N., Poppy, C. L., Smevik, H.,
et al. 2015. Low-dose oxytocin delivered intranasally with breath powered device
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Submitted: 02 December 2015; Accepted: 24 May 2016;
Published online: 06 June 2016.
EDITED BY: Jorge Moll, D’Or Institute for Research and Education (IDOR), Brazil
Citation: Quintana DS and Alvares GA (2016) Oxytocin: How Does This Neuropeptide
Change Our Social Behavior? Front. Young Minds 4:7. doi:10.3389/frym.2016.00007
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conflict of interest STATEMENT: The authors declare that the research was
conducted in the absence of any commercial or inancial relationships that could be
construed as a potential conlict of interest.
Copyright © 2016 Quintana and Alvares. This is an open-access article distributed under
the terms of the Creative Commons Attribution License (CC BY). The use, distribution and
reproduction in other forums is permitted, provided the original author(s) or licensor are
credited and that the original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which does not comply
with these terms.
Reviewed by
St. Bernard Regional Catholic School, 10–13 years old
We are 10–13 years old students from St. Bernard Regional Catholic School. Although we are
small, our knowledge is grand and our curiosity is unlimited. Many of us participate in different
after-school activities, including Girl Scouts, Boy Scouts, sports, and music. We love doing
science experiences and discovering new things in school. When we were approached to
participate in an article review, we were so excited and oh boy, was it a great experience!
Authors
Daniel S. Quintana
I am an Australian researcher, now living in Norway. I study the role of hormones and
physiology in psychological processes. I am especially interested in how both the oxytocin
and cardiovascular systems inluence our social behavior and perceptions. When I am not in
the laboratory I enjoy traveling and being in the outdoors with my wife. *daniel.quintana@
medisin.uio.no
Gail A. Alvares
I am an Australian researcher, originally from Sydney and now living in Perth – the second
most isolated city in the world! I work within a team of researchers investigating the
underlying causes of autism spectrum disorder and testing new interventions. I am
passionate about inding new and better ways to help children with autism spectrum
disorder and their families lead fulilling and happy lives.
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