This study compared metabolic power (MP) and time trial (TT) running performance between Adidas Adizero Adios (AAA) and Nike VaporFly 4% (NVP). Thirty-seven runners completed three laboratory sessions and two field sessions (n=30). After familiarization (visit 1), participants completed eight 6-min treadmill running bouts (four with each shoe, counterbalanced) at their preferred pace, and MP was assessed using indirect calorimetry (visits 2 and 3). During visits 4 and 5, participants completed two outdoor TTs (~3.5 km) in NVP and AAA (counterbalanced). Compared with AAA, NVP exhibited superior MP (NVP: median=13.88 (Q1–Q3=12.90–15.08 W/kg; AAA: median=14.08 (Q1–Q3=13.12–15.44 W/kg; z=−4.81, p<.001, effect size=.56) and TT (NVP=793±98 s; AAA=802±100 s, p=.001; effect size=.09). However, there was no relationship between changes in MP and changes in TT between shoes (r=.151 p=.425, 95% confidence interval=[−.22; .48]). Our results demonstrate that NVP, compared with AAA, improves M...