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2022, Journal of Trace Elements in Medicine and Biology
BackgroundThe present study aimed to assess the therapeutic effects of boron citrate and oleoylethanolamide supplementation in patients with COVID-19.MethodsForty adult patients with a diagnosis of COVID-19 were recruited in the present study. Patients were randomized in a 1:1:1:1 allocation ratio to 1of 4 treatment groups: (A) 5 mg of boron citrate twice a day, (B) 200 mg of oleoylethanolamide twice a day, (C) both therapies, or (D) routine treatments without any study medications. At pre-and post-intervention phase, some clinical and biochemical parameters were assessed.ResultsSupplementation with boron citrate alone or in combination with oleoylethanolamide significantly improved O2 saturation and respiratory rate (p < 0.01). At the end of the study, significant increases in white blood cell and lymphocyte count were observed in the boron citrate and combined groups (p < 0.001). Boron citrate supplementation led to a significant decrease in serum lactate dehydrogenase (p = 0.026) and erythrocyte sedimentation rate (p = 0.014), compared with other groups. Furthermore, boron citrate in combination with oleoylethanolamide resulted in a significant reduction in the high-sensitivity C-reactive protein and interleukin-1β concentrations (p = 0.031 and p = 0.027, respectively). No significant differences were found among four groups post-intervention, in terms of hemoglobin concentrations, platelet count, and serum interleukin-6 levels. At the end of the study, common symptoms of COVID-19 including cough, fatigue, shortness of breath, and myalgia significantly improved in the supplemented groups, compared to the placebo (p < 0.05).ConclusionSupplementation with boron citrate alone or in combination with oleoylethanolamide could improve some clinical and biochemical parameters in COVID-19 patients.
Frontiers in Nutrition
Effectiveness of Borage plus syrup on COVID-19 patients in intensive care unitsIntroductionCOVID-19 (coronavirus disease-2019) still causes a high rate of death globally with no definite curative treatment described. The traditional plant Borage (Borago officinalis L.) is a good source of gamma-linolenic (GLA). We hypothesized that Borage plus syrup (BPS) would be beneficial in severe COVID-19 patients within an intensive care unit (ICU) setting.Materials and methodsA pilot single center, randomized trial with no placebo was undertaken. A total of 60 PCR-positive severe COVID-19 participants admitted to ICU from June 2020–December 2020 at Masih Daneshvari Hospital Tehran-Iran gave informed consent. The participants were randomly assigned to either Borage Plus Syrup (BPS, 5 ml for 5 days) (n = 30) or standard care (IFN-β and favipiravir) as a control group (n = 30). Pao2/Fio2, serum ferritin, CRP, bilirubin, IL-6, TNF-α, ALT, AST, PCT and serum IL-8 was measured upon admission and on release.ResultsAll the measured parameters decreased significantly with BPS tr...
2020 •
Bacillus Calmette−Guérin (BCG) is widely used in national vaccination programs worldwide. It is accepted that BCG alleviates both pathogen and allergy induced respiratory diseases that could also include Covid-19. To investigate this possibility, we randomly assigned 60 Covid-19 patients, after admission to the hospital with pneumonia and requirement for oxygen therapy in a 1:1 ratio to receive either a single adult dose of intradermal BCG or normal saline with concomitant standard of care (SoC) medications. Primary endpoints were favorable prognosis of Covid-19 as deduced from resolution of pneumonia, viremia and secondary outcome were enumeration of ICU admissions, duration thereof and mortalities.ResultsBoth primary and secondary endpoints were significantly improved in the BCG+SoC group. This could be seen from reduction in oxygen requirement due to Covid-19 associated pneumonia decreasing from day 3-4, improved radiological resolution from day 7-15. There were a total of 6 (10%...
Research Square (Research Square)
A randomized controlled trial of adjuvant inhalable sodium bicarbonate role in treatment of COVID-192022 •
The Journal of Trace Elements in Experimental Medicine
Dietary boron: An overview of the evidence for its role in immune function2003 •
2016 •
2020 •
The aim of current study was the investigation of complex treatment including nutritional supplement with recognized antioxidant and immunomodulatory properties (malic, glycyrrhizic, ascorbic and folic acids, glucosamine, arginine, glycine, calcium pantothenate, cyanocobalamine, zinc sulfate, pyridoxal) and purely plant systemic protease supplement (Serrapeptase, Bromelaim, Boswellia, Uncaria tomentosa, Quercetin) as a strategy against Covid 19. A clinical case of a 33-year-old patient treated in Internal Clinic Diseases ”Pirogov” against atypical bilaterally viral pneumonia with RT-PCR proven coronavirus have been presented. A complex treatment strategy was applied: Doxycycline, Amikacin sulfate, food additive containing malic and glycyrhizic acids, aminoacids, B-vitamins, antioxidants, proteolytic agent, Methylprednisolone, anticoagulant: Nadroparin calcium, hepatoprotector: Ademethionine. After 16 days hospitalization and two negative RT-PCR tests the patient was discharged in im...
Journal of Survey in Fisheries Sciences
The effect of the current treatment protocol on some biochemical and inflammatory markers in severe COVID-19 patients2023 •
Treatment of coronavirus infections varied according to the severity of the symptoms, sites, and organs affected. COVID-19 severity ranged from mild, moderate, severe, and critical which may end in death. Disease treatment varied according to the stage, symptoms, and organs affected. Anti-virals, anti-inflammations, anti-bacterial, and anti-coagulants are commonly used in the treatment in addition to the tools helpful in improving respiration. To assess the efficacy of the current protocol used for the treatment of severe COVID-19 patients, forty severe COVID-19 cases admitted to al-Kindy hospital, Baghdad during the period from March 2021 to October 2021 were subjected to some biochemical and immunological tests thought to associate with the response to the therapy, disease progression, and mortality. After ten days of treatment, twenty patients died. When compared to the survivors, dead patients were of higher ages, had higher levels of urea, creatinine, C-reactive protein, interleukin-6, and D-dimer. The correlation test revealed a significant positive correlation between mortality and IL-6 and Ddimer increase. Among all parameters tested in the study, ROC curve analysis showed that Ddimer has the largest area under the curve followed by IL-6 concerning mortality which indicated that these parameters are good predictors for disease progression and mortality outcome.
International Journal of Basic and Clinical Pharmacology
Anti-inflammatory effects of boron alone or as adjuvant with dexamethasone in animal models of chronic and granulomatous inflammation2015 •
Journal of Pediatric Gastroenterology and Nutrition
Effects of Boric Acid and 2-Aminoethoxydiphenyl Borate on Necrotizing Enterocolitis2014 •
The Oxford Handbook of Galen
Galen in Premodern Tibet and China: Impressions and Footprints2024 •
Revista de Direito Civil Contemporâneo
EDITORIAL DA RDCC 35 (Rodrigo Xavier Leonardo)XXVII Simpósio Nacional de História da ANPUH: conhecimento histórico e diálogo social. Natal - RN, 22 a 26 de julho de 2013. http://www.snh2013.anpuh.org/resources/anais/27/1364830898_ARQUIVO_anpuh.artigo.marcia.vasques.2013.pdf
EGITO ROMANO: IDENTIDADE, PODER E STATUS SOCIAL2013 •
University of Pennsylvania Journal of Business Law
REMIC Tax Enforcement as Financial-Market Regulator2014 •
Journal of Biomolecular Structure and Dynamics
Computational designing of a novel subunit vaccine for human cytomegalovirus by employing the immunoinformatics frameworkForum Pedagogiczne
Praca domowa uczniów w edukacji wczesnoszkolnej2020 •
2020 •
arXiv (Cornell University)
Dissolution Dynamics of a Binary Switchable Hydrophilicty Solvent -- Polymer Drop into an Acidic Aqueous Phase2022 •
Journal of Mathematical Physics
Batalin–Vilkovisky integrals in finite dimensions2010 •
2013 •
International advanced research journal in science, engineering and technology
Enhancement of Reducing Sugar Content in Artocarpus heterophyllus (jackfruit) Seed Through Dilute Acid Pretreatment2023 •