Ancient Rome was an Italic civilization that began on the Italian Peninsula as early as the 8th century BC. Located along the Mediterranean Sea and centered on the city of Rome, it expanded to become one of the largest empires in the ancient world with an estimated 50 to 90 million inhabitants (roughly 20% of the world's population) and covering 6.5 million square kilometers (2.5 million sq mi) during its height between the first and second centuries AD.

In its approximately 12 centuries of existence, Roman civilization shifted from a monarchy to a classical republic and then to an increasingly autocratic empire. Through conquest and assimilation, it came to dominate Southern and Western Europe, Asia Minor, North Africa, and parts of Northern and Eastern Europe. Rome was preponderant throughout the Mediterranean region and was one of the most powerful entities of the ancient world. It is often grouped into classical antiquity together with ancient Greece, and their similar cultures and societies are known as the Greco-Roman world.

Ancient Rome played a pivotal role in the history of wine. The earliest influences on the viticulture of the Italian peninsula can be traced to ancient Greeks and the Etruscans. The rise of the Roman Empire saw both technological advances in and burgeoning awareness of winemaking, which spread to all parts of the empire. Rome's influence has had a profound effect on the histories of today's major winemaking regions in France, Germany, Italy, Portugal and Spain.

The Roman belief that wine was a daily necessity made the drink "democratic" and ubiquitous: wine was available to slaves, peasants, women and aristocrats alike. To ensure the steady supply of wine to Roman soldiers and colonists, viticulture and wine production spread to every part of the empire. The economic opportunities presented by trading in wine drew merchants to do business with tribes native to Gaul and Germania, bringing Roman influences to these regions even before the arrival of the Roman military.