This article covers numbered east-west streets in Manhattan, New York City. Major streets have their own linked articles; minor streets are discussed here. The streets do not run exactly east–west, because the grid plan is aligned with the Hudson River rather than with the cardinal directions. "West" is approximately 29 degrees north of true west.

The numbered streets carry crosstown traffic. In general, even-numbered streets are one-way eastbound and odd-numbered streets are one-way west. Several exceptions reverse this. Most wider streets carry two-way traffic, as do a few of the narrow ones.

Streets' names change from West to East (for instance, East 10th Street to West 10th Street) at Broadway below 8th Street, and at Fifth Avenue from 8th Street and above.

Although the numbered streets begin just north of East Houston Street in the East Village, they generally do not extend west into Greenwich Village, which already had streets when the grid plan was laid out by the Commissioners' Plan of 1811. Streets that do continue farther west change direction before reaching the Hudson River. The grid covers the length of the island from 14th Street north. 13th Street would be the southernmost numbered street to span the entire width of Manhattan without changing direction, but it is interrupted by Jackson Square Park.