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TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1gene.[5]
Function
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with IAP, and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors.[6] TRAF1 also functions as a negative regulator of inflammation by interfering with the linear ubiquitination of NEMO downstream of TLR signaling.[7] This explains why TRAF1 polymorphisms cause an increased risk for rheumatic diseases.[8]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Rothe M, Wong SC, Henzel WJ, Goeddel DV (September 1994). "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor". Cell. 78 (4): 681–92. doi:10.1016/0092-8674(94)90532-0. PMID8069916. S2CID28055231.
^Abdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH (2017). "The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease". Nature Immunology. 18 (1): 26–35. doi:10.1038/ni.3618. PMID27893701. S2CID19487408.
^ abcAbdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH (November 2016). "The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease". Nat. Immunol. 18 (1): 26–35. doi:10.1038/ni.3618. PMID27893701. S2CID19487408.
Further reading
Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID11384837.
Boucher LM, Marengère LE, Lu Y, Thukral S, Mak TW (1997). "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily". Biochem. Biophys. Res. Commun. 233 (3): 592–600. doi:10.1006/bbrc.1997.6509. PMID9168896.
Siemienski K, Peters N, Scheurich P, Wajant H (1997). "Organization of the human tumour necrosis factor receptor-associated factor 1 (TRAF1) gene and mapping to chromosome 9q33-34". Gene. 195 (1): 35–9. doi:10.1016/S0378-1119(97)00147-9. PMID9300817.