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From Wikipedia, the free encyclopedia

SERPINB10
Identifiers
AliasesSERPINB10, PI-10, PI10, serpin family B member 10
External IDsOMIM: 602058 MGI: 2138648 HomoloGene: 68430 GeneCards: SERPINB10
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005024

NM_001160307
NM_198028

RefSeq (protein)

NP_005015

NP_001153779
NP_932145

Location (UCSC)Chr 18: 63.9 – 63.94 MbChr 1: 107.46 – 107.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serpin peptidase inhibitor, clade B (ovalbumin), member 10 is a protein that in humans is encoded by the SERPINB10 gene.[5]

Function

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices.[6] A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1, is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000242550Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000092572Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Serpin peptidase inhibitor, clade B (ovalbumin), member 10".
  6. ^ Huber R, Carrell RW (November 1989). "Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins". Biochemistry. 28 (23): 8951–66. doi:10.1021/bi00449a001. PMID 2690952.
  7. ^ * Bartuski AJ, Kamachi Y, Schick C, Overhauser J, Silverman GA (August 1997). "Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3". Genomics. 43 (3): 321–8. doi:10.1006/geno.1997.4827. PMID 9268635.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This page was last edited on 29 November 2023, at 02:44
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