Papers by José Luiz Gomes do Amaral
Brazilian Journal of Anesthesiology (English Edition), 2022
INTRODUCTION Malignant Hyperthermia (MH) is an inherited hypermetabolic syndrome triggered by exp... more INTRODUCTION Malignant Hyperthermia (MH) is an inherited hypermetabolic syndrome triggered by exposure to halogenated anesthetics/succinylcholine. The lack of knowledge regarding this condition might be explained by the rare occurrence of MH reaction and symptoms. METHODS The observational study evaluated 68 patients from 48 families with confirmed or suspected MH susceptibility due to medical history of MH reaction or idiopathic increase of creatine kinase or MH-related myopathies. Participants were assessed by a standardized questionnaire and submitted to physical/neurological examination to assess the characteristics of patients with MH, their knowledge about the disease, and the impact suspected MH had on their daily lives. RESULTS Suspected MH impacted the daily life of 50% of patients, creating difficulties in performing surgical/clinical/dental treatment and problems related to their family life/working/practicing sports. The questionnaire on MH revealed a correct answer score of 62.1 ± 20.8 (mean ± standard deviation) on a scale 0 to 100. Abnormal physical/neurological examination findings were detected in 92.6% of susceptible patients. CONCLUSIONS Suspected MH had impacted the daily lives of most patients, with patients reporting problems even before MH investigation with IVCT. Patients showed a moderate level of knowledge about MH, suggesting the need to implement continuing education programs. MH susceptible patients require regular follow-up by a health team to detect abnormalities during physical and neurological examination.
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Brazilian Journal of Anesthesiology (English Edition), 2019
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Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 2017
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Revista Brasileira de Otorrinolaringologia, 2003
Os níveis de ruído hospitalares encontram-se excessivamente elevados, especialmente no ambiente d... more Os níveis de ruído hospitalares encontram-se excessivamente elevados, especialmente no ambiente de UTI, em decorrência dos inúmeros alarmes e equipamentos, além da conversação da própria equipe hospitalar. Diante disso, esse ambiente, que deveria ser silencioso e tranqüilo, torna-se ruidoso, transformando-se em um grande fator de estresse e podendo gerar distúrbios fisiológicos e psicológicos tanto nos pacientes como nos funcionários dessa unidade. OBJETIVO: O objetivo deste estudo foi verificar o nível de pressão sonora equivalente em uma UTI geral, procurando estabelecer o período de maior exposição e comparando os resultados com as recomendações nacionais e internacionais. FORMA DE ESTUDO: Estudo observacional. MATERIAL E MÉTODO: Medição do ruído ambiental da UTI do Hospital São Paulo através do analisador de ruído modelo 2260 (Brüel & Kjaer), em período total de 6.000 minutos e aferições a cada 27 segundos, configurado da seguinte forma: tempo de resposta rápido (Fast), medindo ...
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Revista Brasileira de Anestesiologia, 2010
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Revista Brasileira de Anestesiologia, 2006
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Brazilian Journal of Anesthesiology, 2009
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Brazilian Journal of Anesthesiology, 2014
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Brazilian Journal of Anesthesiology, 2014
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BMC Anesthesiology, 2014
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Critical Care - CRIT CARE, 2005
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Sao Paulo Medical Journal, 2006
CONTEXT AND OBJECTIVE: Preoperative glucocorticoid administration has been proposed for reducing ... more CONTEXT AND OBJECTIVE: Preoperative glucocorticoid administration has been proposed for reducing postoperative morbidity. This is not widely used before esophageal resection because of incomplete knowledge regarding its effectiveness. The aim here was to assess the effects of preoperative glucocorticoid administration in adults undergoing esophageal resection for esophageal carcinoma. SEARCH STRATEGY: Studies were identified by searching the Cochrane Controlled Trials Register, MEDLINE, EMBASE, Cancer Lit, SCIELO and Cochrane Library, and by manual searching from relevant articles. The last search for clinical trials for this systematic review was performed in December 2004. SELECTION CRITERIA: This review included randomized studies of patients with potentially resectable carcinomas of the esophagus that compared preoperative glucocorticoid administration with placebo. DATA COLLECTION AND ANALYSIS: Data were extracted by the same reviewers, and the trial quality was assessed using ...
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British Journal of Anaesthesia, 2012
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Brazilian Journal of Medical and Biological Research, 2006
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Sao Paulo Medical Journal, 2004
CONTEXT: Thermodilution, which is considered to be a standard technique for measuring the cardiac... more CONTEXT: Thermodilution, which is considered to be a standard technique for measuring the cardiac output in critically ill patients, is not free from relevant risks. There is a need to find alternative, noninvasive, automatic, simple and accurate methods for monitoring cardiac output at the bedside. OBJECTIVE: To compare cardiac output measurements by thermodilution and partial carbon dioxide rebreathing in patients with acute lung injury at two levels of severity (lung injury score, LIS: below 2.5, group A; and above 2.5, group B). TYPE OF STUDY: Comparative, prospective and controlled study. SETTING: Intensive Care Units of two university hospitals. METHODS: Cardiac output was measured by thermodilution and partial carbon dioxide rebreathing. Twenty patients with acute lung failure (PaO2/FiO2 < 300) who were under mechanical ventilation and from whom 294 measurements were taken: 164 measurements in group A (n = 11) and 130 in group B (n = 9), ranging from 14 to 15 determination...
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Brazilian Journal of Anesthesiology, 2010
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Revista Neurociências, 2019
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Brazilian Journal of Anesthesiology (English Edition), 2019
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Brazilian Journal of Anesthesiology, 2019
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Brazilian Journal of Anesthesiology, 2017
Resumo Justificativa/objetivos Distrofia muscular de Duchenne/Becker afeta a musculatura esquelet... more Resumo Justificativa/objetivos Distrofia muscular de Duchenne/Becker afeta a musculatura esqueletica e leva a fraqueza muscular progressiva e risco de reacoes atipicas anestesicas apos exposicao a succinilcolina ou halogenados. O objetivo do presente relato e descrever investigacao e diagnostico de paciente com distrofia muscular de Becker e revisar os cuidados necessarios na anestesia. Relato de caso Paciente masculino, 14 anos, encaminhado por hiperCKemia (aumento cronico dos niveis sericos de creatinoquinase – CK), com valores de CK de 7.779–29.040 UI.L −1 (normal 174 UI.L −1 ). Apresentou discreto atraso da aquisicao de marcos motores (sentou aos nove meses, andou aos 18). Antecedente de transplante hepatico. No exame neurologico apresentava dificuldade para andar nos calcanhares, levantar miopatico (apoiava maos nas coxas para ficar de pe), palato arqueado alto, hipertrofia de panturrilhas, escapulas aladas, hipotonia muscular global e arreflexia. Havia insuficiencia respiratoria restritiva leve na espirometria (capacidade vital forcada: 77% do previsto). O teste de contratura muscular in vitro em resposta ao halotano e a cafeina foi normal. Estudo da distrofina muscular por tecnica de Western blot mostrou reducao da distrofina (20% do normal) para ambos os anticorpos (C e N‐terminal), e permitiu o diagnostico de distrofia muscular de Becker. Conclusao Na avaliacao pre‐anestesica, historia de atraso do desenvolvimento motor, bem como sinais clinicos e/ou laboratoriais de miopatia, deve motivar avaliacao neurologica, com o objetivo de diagnosticar miopatias subclinicas e planejar cuidados necessarios para prevenir complicacoes anestesicas. Distrofia muscular de Duchenne/Becker, apesar de nao conferir suscetibilidade aumentada a HM, pode levar a reacoes atipicas fatais na anestesia.
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Papers by José Luiz Gomes do Amaral