Absfracf: The thermal and electrical properties of poly(propy1ene terephthalate) samples with dif... more Absfracf: The thermal and electrical properties of poly(propy1ene terephthalate) samples with different carboxyl terminal groups content are investigated. The thermal behavior is studied through the rate of crystallization. As regards the electrical properties, dc conductivity and lowfrequency relaxation processes are studied as a function of temperature. A transition in the electrical behavior is detected and related to the glass transition of the polymer.
Materials with low elastic modulus (E) are expected to satisfy the required compliance of soft ti... more Materials with low elastic modulus (E) are expected to satisfy the required compliance of soft tissue engineering applications (E in the range 0.1-100 MPa, according to the specific native tissue). Accordingly, the interest towards new elastomeric materials with controllable degradation profiles has increased significantly in the last decade. In this work we propose reactive blending as a simple and versatile solvent-free synthetic approach to produce new biomaterials exhibiting elastomeric properties. Newly synthesized copolyether-esters are obtained by melt mixing poly(butylene succinate) (PBS) and poly(triethylene succinate) (PTES)
XIX Convegno Italiano di Scienza e Tecnologia delle Macromolecole, 2009
L\u2019utilizzo di costrutti tessutali ingegnerizzati sviluppati in vitro e destinati ad essere i... more L\u2019utilizzo di costrutti tessutali ingegnerizzati sviluppati in vitro e destinati ad essere impiantati in vivo per promuovere la rigenerazione di un tessuto danneggiato alimenta notevoli speranze nel campo della medicina rigenerativa e dell\u2019ingegneria dei tessuti. Un aspetto critico nell'ingegneria dei tessuti riguarda la necessit\ue0 di avvicinarsi alla tridimensionalit\ue0 del contesto naturale, cio\ue8 mimare la struttura fibrillare 3D della matrice extracellulare (ECM). L\u2019elettrofilatura \ue8 una tecnologia promettente per la fabbricazione di biomateriali in forma di fibre sub-micrometriche che richiamano l'ECM e generano per le cellule un contesto paragonabile a quello nativo. Nonostante ci\uf2, molta ricerca rimane ancora da compiere per fabbricare scaffold con propriet\ue0 meccaniche idonee alle specifiche applicazioni. In particolare, per l\u2019utilizzo nell\u2019ambito dell\u2019ingegneria del tessuto cardiaco al materiale sono richieste propriet\ue0 meccaniche elastiche per consentire l\u2019espansione e la contrazione dello scaffold quando sottoposto a sollecitazioni cicliche in condizioni fisiologiche. Molti sforzi di ricerca sono quindi tutt\u2019oggi dedicati allo sviluppo di nuovi polimeri con modulo elastico (E) adeguato per l\u2019ingegneria del tessuto cardiaco. In questo lavoro si \ue8 sintetizzato un nuovo copoliestere biodegradabile a base di poli(butilene succinato) (PBS) per la realizzazione di scaffold elettrofilati che superino le limitazioni imposte dall'elevato modulo elastico dei materiali polimerici attualmente disponibili. \uc9 stata poi dimostrata la biocompatibilit\ue0 dei nuovi scaffold con cellule embrionali cardiache da ratto
Nanostructured electrospun three-dimensional scaffolds are used for tissue engineering applicatio... more Nanostructured electrospun three-dimensional scaffolds are used for tissue engineering applications i.e. as a guide for cellular growth. Re-absorbable polymers, such as Poly(L)lactide (PLLA) were electrospun using an "ad hoc" collecting device originally designed and realized to allow fabrication of various oriented and patterned fibrous structures. Good cell adhesion, proliferation, and colonization of the scaffold were obtained
The development of an eco-friendly item implies the design of a sustainable material. Such a liai... more The development of an eco-friendly item implies the design of a sustainable material. Such a liaison is crucial in the biomedical field, where disposable devices are used in a broad range of applications, i.e. blisters, sutures, implants, scaffolds for tissue engineering and controlled drug delivery systems. As a consequence, the choice of biodegradable and healthy solutions, given their contact with human body, is a fundamental pre-requisite. In this view, this paper compares a set of noteworthy existing PBS-based biodegradable polyesters in order to summarize their main properties and support designers during the material selection step, by following a life cycle thinking perspective
Absfracf: The thermal and electrical properties of poly(propy1ene terephthalate) samples with dif... more Absfracf: The thermal and electrical properties of poly(propy1ene terephthalate) samples with different carboxyl terminal groups content are investigated. The thermal behavior is studied through the rate of crystallization. As regards the electrical properties, dc conductivity and lowfrequency relaxation processes are studied as a function of temperature. A transition in the electrical behavior is detected and related to the glass transition of the polymer.
Materials with low elastic modulus (E) are expected to satisfy the required compliance of soft ti... more Materials with low elastic modulus (E) are expected to satisfy the required compliance of soft tissue engineering applications (E in the range 0.1-100 MPa, according to the specific native tissue). Accordingly, the interest towards new elastomeric materials with controllable degradation profiles has increased significantly in the last decade. In this work we propose reactive blending as a simple and versatile solvent-free synthetic approach to produce new biomaterials exhibiting elastomeric properties. Newly synthesized copolyether-esters are obtained by melt mixing poly(butylene succinate) (PBS) and poly(triethylene succinate) (PTES)
XIX Convegno Italiano di Scienza e Tecnologia delle Macromolecole, 2009
L\u2019utilizzo di costrutti tessutali ingegnerizzati sviluppati in vitro e destinati ad essere i... more L\u2019utilizzo di costrutti tessutali ingegnerizzati sviluppati in vitro e destinati ad essere impiantati in vivo per promuovere la rigenerazione di un tessuto danneggiato alimenta notevoli speranze nel campo della medicina rigenerativa e dell\u2019ingegneria dei tessuti. Un aspetto critico nell'ingegneria dei tessuti riguarda la necessit\ue0 di avvicinarsi alla tridimensionalit\ue0 del contesto naturale, cio\ue8 mimare la struttura fibrillare 3D della matrice extracellulare (ECM). L\u2019elettrofilatura \ue8 una tecnologia promettente per la fabbricazione di biomateriali in forma di fibre sub-micrometriche che richiamano l'ECM e generano per le cellule un contesto paragonabile a quello nativo. Nonostante ci\uf2, molta ricerca rimane ancora da compiere per fabbricare scaffold con propriet\ue0 meccaniche idonee alle specifiche applicazioni. In particolare, per l\u2019utilizzo nell\u2019ambito dell\u2019ingegneria del tessuto cardiaco al materiale sono richieste propriet\ue0 meccaniche elastiche per consentire l\u2019espansione e la contrazione dello scaffold quando sottoposto a sollecitazioni cicliche in condizioni fisiologiche. Molti sforzi di ricerca sono quindi tutt\u2019oggi dedicati allo sviluppo di nuovi polimeri con modulo elastico (E) adeguato per l\u2019ingegneria del tessuto cardiaco. In questo lavoro si \ue8 sintetizzato un nuovo copoliestere biodegradabile a base di poli(butilene succinato) (PBS) per la realizzazione di scaffold elettrofilati che superino le limitazioni imposte dall'elevato modulo elastico dei materiali polimerici attualmente disponibili. \uc9 stata poi dimostrata la biocompatibilit\ue0 dei nuovi scaffold con cellule embrionali cardiache da ratto
Nanostructured electrospun three-dimensional scaffolds are used for tissue engineering applicatio... more Nanostructured electrospun three-dimensional scaffolds are used for tissue engineering applications i.e. as a guide for cellular growth. Re-absorbable polymers, such as Poly(L)lactide (PLLA) were electrospun using an "ad hoc" collecting device originally designed and realized to allow fabrication of various oriented and patterned fibrous structures. Good cell adhesion, proliferation, and colonization of the scaffold were obtained
The development of an eco-friendly item implies the design of a sustainable material. Such a liai... more The development of an eco-friendly item implies the design of a sustainable material. Such a liaison is crucial in the biomedical field, where disposable devices are used in a broad range of applications, i.e. blisters, sutures, implants, scaffolds for tissue engineering and controlled drug delivery systems. As a consequence, the choice of biodegradable and healthy solutions, given their contact with human body, is a fundamental pre-requisite. In this view, this paper compares a set of noteworthy existing PBS-based biodegradable polyesters in order to summarize their main properties and support designers during the material selection step, by following a life cycle thinking perspective
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Papers by Nadia Lotti