Pakistan Journal of Medical and Health Sciences, 2021
Objective: The global incidence of autism has rised up. It can appear the importance of intervent... more Objective: The global incidence of autism has rised up. It can appear the importance of interventions and family struggles, because music is attractive for children we can use it as an effective intervention. The goal of this article is a review of the ASD children problems and interventions and the music effects for treating children with Autism Spectrum Disorder (ASD). Finally, since music is always accessible and the human body utilizes it on a daily basis, we can use music as a complementary method in occupational therapy. Materials & Methods: Comprehensive electronic search of keywords "music therapy", "autism interventions" and "vagus nerve stimulation" was done in international electronic databases such as PubMed, Scopus, Google Scholar and Google Books between 2000 and 2021. In the first part of the search, based on the considered keywords, 30,446 articles were obtained. After reviewing the abstracts of articles, 30,405 articles were discarded d...
Adult neurogenesis is the process of producing new neurons in the adult brain and is limited to t... more Adult neurogenesis is the process of producing new neurons in the adult brain and is limited to two major areas: the hippocampal dentate gyrus and the Subventricular Zone (SVZ). Adult neurogenesis is affected by some physiological, pharmacological, and pathological factors. The inflammasome is a major signalling platform that regulates caspase-1 and induces proinflammatory cytokines production such as interleukin-1β (IL1-β) and IL-18. Inflammasomes may be stimulated through multiple signals, and some of these signaling factors can affect neurogenesis. In the current review, “adult neurogenesis and inflammasome” were searched in PubMed, Scopus, and Google Scholar. Reviewing various research works showed correlations between inflammasome and neurogenesis by different intermediate factors, such as interferons (IFN), interleukins (IL), α-synuclein, microRNAs, and natural compounds. Concerning the significant role of neurogenesis in the health of the nervous system and memory, understand...
The aim of the present study was to evaluate the effectiveness of human ovarian vitrification pro... more The aim of the present study was to evaluate the effectiveness of human ovarian vitrification protocol followed with in vitro culture at the morphological and molecular levels. Ovarian tissues were obtained from 10 normal transsexual women and cut into small pieces and were divided into non-vitrified and vitrified groups and some of the tissues fragments in both groups were randomly cultured for two weeks. The morphological study using hematoxylin and eosin and Masson's trichrome staining was done. The analysis of mean follicular density, 17-β estradiol (E2) and anti mullerian hormone (AMH), and real-time RT-PCR was down for the evaluation of expression of genes related to folliculogenesis. Data were compared by paired-samples and independent-samples T test. Values of p<0.05 were considered statistically significant. The proportion of normal follicles did not show significant difference between vitrified and non-vitrified groups before and after culture but these rates and th...
Objective: This study aimed to evaluate the effect of vitrification on the morphology of human ov... more Objective: This study aimed to evaluate the effect of vitrification on the morphology of human ovarian tissue in a stimulated group compared to a non-stimulated group. Methods: Ovarian cortex biopsies collected from stimulated and non-stimulated groups were transported to the laboratory in L-15 medium. Biopsies were cut into small pieces and divided randomly into the vitrified and non-vitrified subgroups. The vitrified-warmed and fresh samples were fixed using Bouin's solution, then passaged, sectioned and stained with hematoxylin and eosin and Masson's trichrome. The follicles at different developmental stages were counted and evaluated. Results: Morphological observations showed that the follicles and stromal tissue had well preserved normal structures after vitrification and warming. The percentage of normal follicles in the non-stimulated non-vitrified group was 89.22%; for the non-stimulated vitrified group, it was 84.60%. In previous groups the proportion of primordial...
Migraine is a common disorder which is placed among the top ten reasons of years lived with disab... more Migraine is a common disorder which is placed among the top ten reasons of years lived with disability. Cytokines are among the molecules that contribute in the pathophysiology of migraine. In the current study, we evaluated expression levels of IL-6 coding gene in the peripheral blood of 120 migraine patients (54 migraine without aura and 66 migraine with aura patients) and 40 healthy subjects. No significant difference was detected in expression of IL-6 between total migraine patients and healthy controls (Posterior beta = 0.253, P value = 0.199). The interaction effect between gender and group was significant (Posterior beta =-1.274, P value = 0.011), therefore, we conducted subgroup analysis within gender group. Such analysis revealed that while expression of this gene is not different between male patients and male controls (Posterior beta =-0.371, P value > 0.999), it was significantly over-expressed in female patients compared with female controls (Posterior beta = 0.86, P...
Pakistan Journal of Medical and Health Sciences, 2021
Human body has energy which determines you are sick, tired, bored, excited and angry or not. Acco... more Human body has energy which determines you are sick, tired, bored, excited and angry or not. According to Physics music is placed in energy spectrum as one part of sounds and volumes, which can affect our body energy. On the other side the rhythmical and compositionality feature of music reinforces this consequence, due to these features, music is more populare than the other hobbies. We often use music in our daily lives, for example, from ringing the doorbell to using the phone or waiting in the elevator to reach the desired floor and etc. it is one common and available supplementary that human can use it for treating different diseases. The music plays an important role in activation of parasympathetic part via the vagus nerve stimulation. The vagus nerve is a tenth nerve of twelve cerebral nerves. The tenth nerve is one of the most important nerves which originates from the brain and is responsible for innervating face, thorax, abdomen and etc. It is a motor sensory nerve. The v...
AimsOxidative stress and neuronal death are the primary reasons for the progression of amyloid-be... more AimsOxidative stress and neuronal death are the primary reasons for the progression of amyloid-beta (Aβ) deposition and cognitive deficits in Alzheimer’s disease (AD). Ecdysterone, a common derivative of ecdysteroids, possesses free radical scavenging and cognitive-improving effects. High-intensity interval training (HIIT) may be a therapeutic strategy for improving cognitive decline and oxidative stress. The present study was aimed to evaluate the effect of HIIT alone and its combination with Ecdysterone on the changes in learning and memory functions, hippocampal antioxidant enzymes activities, and neuronal population after AD induced by Aβ in male rats. Materials and methodsFollowing ten days of Aβ-injection, HIIT exercise and Ecdysterone treatment (10 mg/kg/day; P.O.) were initiated and continued for eight consecutive weeks in rats. At the end of the treatment period, rat’s learning and memory functions were assessed using water-maze and passive-avoidance tests. Moreover, the ac...
The journal of obstetrics and gynaecology research, Jan 5, 2018
The study assesses the effect of the vitrification procedure on the integrity, morphology, follic... more The study assesses the effect of the vitrification procedure on the integrity, morphology, follicular development and gene expression of stimulated human ovarian tissue after warming and two weeks of in vitro culture. Ovarian specimens were divided into non-vitrified and vitrified groups and were cultured for two weeks. Morphological analysis and immunohistochemistry were performed. The 17-β estradiol and anti-Müllerian hormone levels in collected media were assessed. Gene expression was analyzed using real-time reverse transcription polymerase chain reaction. The morphology and immunohistochemistry of bcl-2-like protein 4 and B-cell lymphoma 2 of human stimulated ovarian tissue were similar in both groups. There was no significant difference in the percentage of normal follicles between the groups before and after in vitro culture. In spite of an increase in the percentage of growing follicles in cultured tissues compared to the non-cultured groups, the rate of normal follicles was...
Pakistan Journal of Medical and Health Sciences, 2021
Objective: The global incidence of autism has rised up. It can appear the importance of intervent... more Objective: The global incidence of autism has rised up. It can appear the importance of interventions and family struggles, because music is attractive for children we can use it as an effective intervention. The goal of this article is a review of the ASD children problems and interventions and the music effects for treating children with Autism Spectrum Disorder (ASD). Finally, since music is always accessible and the human body utilizes it on a daily basis, we can use music as a complementary method in occupational therapy. Materials & Methods: Comprehensive electronic search of keywords "music therapy", "autism interventions" and "vagus nerve stimulation" was done in international electronic databases such as PubMed, Scopus, Google Scholar and Google Books between 2000 and 2021. In the first part of the search, based on the considered keywords, 30,446 articles were obtained. After reviewing the abstracts of articles, 30,405 articles were discarded d...
Adult neurogenesis is the process of producing new neurons in the adult brain and is limited to t... more Adult neurogenesis is the process of producing new neurons in the adult brain and is limited to two major areas: the hippocampal dentate gyrus and the Subventricular Zone (SVZ). Adult neurogenesis is affected by some physiological, pharmacological, and pathological factors. The inflammasome is a major signalling platform that regulates caspase-1 and induces proinflammatory cytokines production such as interleukin-1β (IL1-β) and IL-18. Inflammasomes may be stimulated through multiple signals, and some of these signaling factors can affect neurogenesis. In the current review, “adult neurogenesis and inflammasome” were searched in PubMed, Scopus, and Google Scholar. Reviewing various research works showed correlations between inflammasome and neurogenesis by different intermediate factors, such as interferons (IFN), interleukins (IL), α-synuclein, microRNAs, and natural compounds. Concerning the significant role of neurogenesis in the health of the nervous system and memory, understand...
The aim of the present study was to evaluate the effectiveness of human ovarian vitrification pro... more The aim of the present study was to evaluate the effectiveness of human ovarian vitrification protocol followed with in vitro culture at the morphological and molecular levels. Ovarian tissues were obtained from 10 normal transsexual women and cut into small pieces and were divided into non-vitrified and vitrified groups and some of the tissues fragments in both groups were randomly cultured for two weeks. The morphological study using hematoxylin and eosin and Masson's trichrome staining was done. The analysis of mean follicular density, 17-β estradiol (E2) and anti mullerian hormone (AMH), and real-time RT-PCR was down for the evaluation of expression of genes related to folliculogenesis. Data were compared by paired-samples and independent-samples T test. Values of p<0.05 were considered statistically significant. The proportion of normal follicles did not show significant difference between vitrified and non-vitrified groups before and after culture but these rates and th...
Objective: This study aimed to evaluate the effect of vitrification on the morphology of human ov... more Objective: This study aimed to evaluate the effect of vitrification on the morphology of human ovarian tissue in a stimulated group compared to a non-stimulated group. Methods: Ovarian cortex biopsies collected from stimulated and non-stimulated groups were transported to the laboratory in L-15 medium. Biopsies were cut into small pieces and divided randomly into the vitrified and non-vitrified subgroups. The vitrified-warmed and fresh samples were fixed using Bouin's solution, then passaged, sectioned and stained with hematoxylin and eosin and Masson's trichrome. The follicles at different developmental stages were counted and evaluated. Results: Morphological observations showed that the follicles and stromal tissue had well preserved normal structures after vitrification and warming. The percentage of normal follicles in the non-stimulated non-vitrified group was 89.22%; for the non-stimulated vitrified group, it was 84.60%. In previous groups the proportion of primordial...
Migraine is a common disorder which is placed among the top ten reasons of years lived with disab... more Migraine is a common disorder which is placed among the top ten reasons of years lived with disability. Cytokines are among the molecules that contribute in the pathophysiology of migraine. In the current study, we evaluated expression levels of IL-6 coding gene in the peripheral blood of 120 migraine patients (54 migraine without aura and 66 migraine with aura patients) and 40 healthy subjects. No significant difference was detected in expression of IL-6 between total migraine patients and healthy controls (Posterior beta = 0.253, P value = 0.199). The interaction effect between gender and group was significant (Posterior beta =-1.274, P value = 0.011), therefore, we conducted subgroup analysis within gender group. Such analysis revealed that while expression of this gene is not different between male patients and male controls (Posterior beta =-0.371, P value > 0.999), it was significantly over-expressed in female patients compared with female controls (Posterior beta = 0.86, P...
Pakistan Journal of Medical and Health Sciences, 2021
Human body has energy which determines you are sick, tired, bored, excited and angry or not. Acco... more Human body has energy which determines you are sick, tired, bored, excited and angry or not. According to Physics music is placed in energy spectrum as one part of sounds and volumes, which can affect our body energy. On the other side the rhythmical and compositionality feature of music reinforces this consequence, due to these features, music is more populare than the other hobbies. We often use music in our daily lives, for example, from ringing the doorbell to using the phone or waiting in the elevator to reach the desired floor and etc. it is one common and available supplementary that human can use it for treating different diseases. The music plays an important role in activation of parasympathetic part via the vagus nerve stimulation. The vagus nerve is a tenth nerve of twelve cerebral nerves. The tenth nerve is one of the most important nerves which originates from the brain and is responsible for innervating face, thorax, abdomen and etc. It is a motor sensory nerve. The v...
AimsOxidative stress and neuronal death are the primary reasons for the progression of amyloid-be... more AimsOxidative stress and neuronal death are the primary reasons for the progression of amyloid-beta (Aβ) deposition and cognitive deficits in Alzheimer’s disease (AD). Ecdysterone, a common derivative of ecdysteroids, possesses free radical scavenging and cognitive-improving effects. High-intensity interval training (HIIT) may be a therapeutic strategy for improving cognitive decline and oxidative stress. The present study was aimed to evaluate the effect of HIIT alone and its combination with Ecdysterone on the changes in learning and memory functions, hippocampal antioxidant enzymes activities, and neuronal population after AD induced by Aβ in male rats. Materials and methodsFollowing ten days of Aβ-injection, HIIT exercise and Ecdysterone treatment (10 mg/kg/day; P.O.) were initiated and continued for eight consecutive weeks in rats. At the end of the treatment period, rat’s learning and memory functions were assessed using water-maze and passive-avoidance tests. Moreover, the ac...
The journal of obstetrics and gynaecology research, Jan 5, 2018
The study assesses the effect of the vitrification procedure on the integrity, morphology, follic... more The study assesses the effect of the vitrification procedure on the integrity, morphology, follicular development and gene expression of stimulated human ovarian tissue after warming and two weeks of in vitro culture. Ovarian specimens were divided into non-vitrified and vitrified groups and were cultured for two weeks. Morphological analysis and immunohistochemistry were performed. The 17-β estradiol and anti-Müllerian hormone levels in collected media were assessed. Gene expression was analyzed using real-time reverse transcription polymerase chain reaction. The morphology and immunohistochemistry of bcl-2-like protein 4 and B-cell lymphoma 2 of human stimulated ovarian tissue were similar in both groups. There was no significant difference in the percentage of normal follicles between the groups before and after in vitro culture. In spite of an increase in the percentage of growing follicles in cultured tissues compared to the non-cultured groups, the rate of normal follicles was...
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Papers by Mahdi Ramezani