Papers by Brannon McCullough
Journal of Molecular Biology, Sep 1, 2008
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Bulletin of the American Physical Society, Feb 28, 2012
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Biophysical Journal, 2012
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Biophysical Journal, Sep 1, 2010
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Biophysical Journal, 2014
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Proceedings of the National Academy of Sciences of the United States of America, Oct 1, 2012
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Nature communications, Jan 22, 2017
Cell migration, which is central to many biological processes including wound healing and cancer ... more Cell migration, which is central to many biological processes including wound healing and cancer progression, is sensitive to environmental stiffness, and many cell types exhibit a stiffness optimum, at which migration is maximal. Here we present a cell migration simulator that predicts a stiffness optimum that can be shifted by altering the number of active molecular motors and clutches. This prediction is verified experimentally by comparing cell traction and F-actin retrograde flow for two cell types with differing amounts of active motors and clutches: embryonic chick forebrain neurons (ECFNs; optimum ∼1 kPa) and U251 glioma cells (optimum ∼100 kPa). In addition, the model predicts, and experiments confirm, that the stiffness optimum of U251 glioma cell migration, morphology and F-actin retrograde flow rate can be shifted to lower stiffness by simultaneous drug inhibition of myosin II motors and integrin-mediated adhesions.
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Biophysical Journal, 2014
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Biophysical Journal, 2014
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Biophysical Journal, 2015
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PLoS ONE, 2014
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Biophysical reviews, 2009
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Current biology: …, 2011
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Biophysical …, 2012
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Bulletin of the American …, 2012
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Bulletin of the American Physical …, 2012
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Proceedings of the …, 2012
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Journal of Molecular Biology, 2011
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Papers by Brannon McCullough