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Progress in low-field benchtop NMR spectroscopy in chemical and biochemical analysis

Anal Chim Acta. 2019 Aug 27:1067:11-30. doi: 10.1016/j.aca.2019.02.026. Epub 2019 Feb 23.

Abstract

The employment of spectroscopically-resolved NMR techniques as analytical probes have previously been both prohibitively expensive and logistically challenging in view of the large sizes of high-field facilities. However, with recent advances in the miniaturisation of magnetic resonance technology, low-field, cryogen-free "benchtop" NMR instruments are seeing wider use. Indeed, these miniaturised spectrometers are utilised in areas ranging from food and agricultural analyses, through to human biofluid assays and disease monitoring. Therefore, it is both intrinsically timely and important to highlight current applications of this analytical strategy, and also provide an outlook for the future, where this approach may be applied to a wider range of analytical problems, both qualitatively and quantitatively.

Keywords: Benchtop NMR; Biofluid analysis; Compact NMR; Mobile NMR.

Publication types

  • Review

MeSH terms

  • Animals
  • Body Fluids / chemistry*
  • Disease
  • Forensic Medicine
  • Humans
  • Magnetic Resonance Spectroscopy / instrumentation*
  • Magnetic Resonance Spectroscopy / methods*
  • Point-of-Care Systems