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Click-functionalized compact quantum dots protected by multidentate-imidazole ligands: conjugation-ready nanotags for living-virus labeling and imaging

J Am Chem Soc. 2012 May 23;134(20):8388-91. doi: 10.1021/ja302367s. Epub 2012 May 11.

Abstract

We synthesized a new class of mutifunctional multidentate-imidazole polymer ligands by one-step reaction to produce conjugation-ready QDs with great stability and compact size. Furthermore, combined with strain-promoted click chemistry, we developed a general strategy for efficient labeling of living-viruses with QD probes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cell Proliferation
  • Click Chemistry
  • Fluorescent Dyes / chemistry*
  • Humans
  • Hydrodynamics
  • Imidazoles / chemistry*
  • Ligands
  • Microscopy, Fluorescence* / methods
  • Models, Molecular
  • Quantum Dots*
  • Virus Internalization
  • Virus Physiological Phenomena
  • Viruses / isolation & purification*
  • Viruses / ultrastructure

Substances

  • Fluorescent Dyes
  • Imidazoles
  • Ligands