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Immunochromatography for the rapid determination of cadmium concentrations in wheat grain and eggplant

J Sci Food Agric. 2011 Jun;91(8):1392-7. doi: 10.1002/jsfa.4321. Epub 2011 Feb 18.

Abstract

Background: A simple and quick on-site test for trace levels of cadmium (Cd) in food is needed because of the human toxicity of this heavy metal. We developed an immunochromatography kit which uses the antigen-antibody complex reaction between the Cd-ethylenediaminetetraacetic acid (Cd-EDTA) complex and an anti-Cd-EDTA antibody. We previously reported the successful use of this kit to determine Cd concentrations in brown rice with respect to the international standard: 0.4 mg kg⁻¹. Here, we measured, using this immunochromatography kit, Cd concentrations in crops with lower international standards than rice.

Results: Cadmium extracted with 0.1 mol L⁻¹ HCl from wheat grain and fresh eggplant was purified sufficiently using an ion-exchange column treatment. Appropriate HCl extraction rates and dilution rates for the column eluate were selected; Cd concentrations in wheat grain and fresh eggplant were determined successfully by immunochromatography with respect to the international standards of 0.2 mg kg⁻¹ and 0.05 mg kg⁻¹ fresh weight, respectively.

Conclusion: Approximate Cd concentrations in wheat grain and fresh eggplant can be monitored easily and quickly by this method at locations where facilities for acid digestion and precision analysis are not available.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cadmium / analysis*
  • Cadmium / isolation & purification
  • Chromatography / methods*
  • Edetic Acid / immunology
  • Edible Grain / chemistry
  • Food Analysis / methods*
  • Fruit / chemistry
  • Humans
  • Immunoassay / methods
  • Plant Extracts / analysis*
  • Plant Extracts / chemistry
  • Reference Values
  • Solanum melongena / chemistry*
  • Trace Elements / analysis*
  • Trace Elements / isolation & purification
  • Triticum / chemistry*

Substances

  • Plant Extracts
  • Trace Elements
  • Cadmium
  • Edetic Acid