Abstract
A comparative proteomic analysis of neoplastic versus non-neoplastic seminoma identified glutathione S-transferase M3 as a differentially expressed protein. This expression difference could also be observed at the mRNA level, implying neoplasm-associated alterations in transcriptional or post-transcriptional mechanisms.
MeSH terms
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Biomarkers / analysis
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Biomarkers / metabolism
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Electrophoresis, Gel, Two-Dimensional
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Gene Expression Regulation, Neoplastic
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Germ Cells / cytology
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Germ Cells / enzymology*
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Glutathione Transferase / analysis
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Glutathione Transferase / genetics
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Glutathione Transferase / metabolism*
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Humans
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Male
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Mass Spectrometry
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Proteomics
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RNA, Messenger / metabolism
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Seminoma / enzymology*
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Testicular Neoplasms / enzymology*
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Transcription, Genetic
Substances
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Biomarkers
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RNA, Messenger
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GSTM3 protein, human
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Glutathione Transferase