Abstract
The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Biological Evolution
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Codon
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DNA Replication
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DNA, Mitochondrial / genetics*
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Genes
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Humans
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Nucleic Acid Precursors / metabolism
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Peptide Chain Initiation, Translational
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Peptide Chain Termination, Translational
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RNA, Ribosomal / genetics
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RNA, Transfer / genetics
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Transcription, Genetic
Substances
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Codon
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DNA, Mitochondrial
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Nucleic Acid Precursors
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RNA, Ribosomal
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RNA, Transfer
Associated data
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GENBANK/J01415
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GENBANK/M12548