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TNF tumor necrosis factor [ Pan troglodytes (chimpanzee) ]

Gene ID: 494186, updated on 29-Mar-2024

Summary

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Gene symbol
TNF
Gene description
tumor necrosis factor
Locus tag
CK820_G0006842
See related
Ensembl:ENSPTRG00000017965
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as
TNFA; TNF-a; TNLG1F
Orthologs
human mouse all
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Genomic context

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See TNF in Genome Data Viewer
Location:
chromosome: 5
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 5 NC_072403.2 (37372673..37375469)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 6 NC_072404.1 (37371544..37375686)

Chromosome 5 - NC_072403.2Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor like 1 Neighboring gene lymphotoxin alpha Neighboring gene lymphotoxin beta Neighboring gene leukocyte specific transcript 1 Neighboring gene natural cytotoxicity triggering receptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative genomic analysis of the MHC: the evolution of class I duplication blocks, diversity and complexity from shark to man. Kulski JK, et al. Immunol Rev, 2002 Dec. PMID 12493009
  2. Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence. Anzai T, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12799463, Free PMC Article
  3. Comparative genomic analysis of eutherian tumor necrosis factor ligand genes. Premzl M. Immunogenetics, 2016 Feb. PMID 26646413
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor
Names
TNF-alpha
cachectin
tumor necrosis factor (TNF superfamily, member 2)
tumor necrosis factor ligand 1F
tumor necrosis factor ligand superfamily member 2
tumor necrosis factor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045511.1 → NP_001038976.1  tumor necrosis factor

    See identical proteins and their annotated locations for NP_001038976.1

    Status: PROVISIONAL

    Source sequence(s)
    BA000041
    UniProtKB/Swiss-Prot
    Q1XHZ6, Q8HZD9
    UniProtKB/TrEMBL
    A0A2I3RZ61
    Conserved Domains (1) summary
    pfam00229
    Location:101 → 232
    TNF; TNF(Tumour Necrosis Factor) family

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072403.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    37372673..37375469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016954737.3 → XP_016810226.1  tumor necrosis factor isoform X1

    UniProtKB/TrEMBL
    A0A0U5J3S4, A0A2I3RZ61, A0A2J8NXQ7, A0A663DHG4
    Related
    ENSPTRP00000054518.4
    Conserved Domains (1) summary
    pfam00229
    Location:103 → 233
    TNF; TNF(tumor Necrosis Factor) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8HZD9.2 GenPept UniProtKB/Swiss-Prot:Q8HZD9

Gene LinkOut

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