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TNF tumor necrosis factor [ Pongo pygmaeus (Bornean orangutan) ]

Gene ID: 129038427, updated on 26-Mar-2024

Summary

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Gene symbol
TNF
Gene description
tumor necrosis factor
Gene type
protein coding
RefSeq status
MODEL
Organism
Pongo pygmaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs
human mouse all
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Genomic context

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See TNF in Genome Data Viewer
Location:
chromosome: 5
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonPyg2-v2.0_pri (GCF_028885625.2) 5 NC_072378.2 (31898655..31901476)
RS_2023_04 previous assembly NHGRI_mPonPyg2-v1.1-hic.freeze_pri (GCF_028885625.1) 6 NC_072379.1 (31788442..31791263)

Chromosome 5 - NC_072378.2Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor like 1 Neighboring gene lymphotoxin alpha Neighboring gene lymphotoxin beta Neighboring gene leukocyte specific transcript 1 Neighboring gene natural cytotoxicity triggering receptor 3 Neighboring gene cytochrome b-c1 complex subunit 6, mitochondrial-like Neighboring gene allograft inflammatory factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor
Names
tumour necrosis factor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028885625.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonPyg2-v2.0_pri Primary Assembly

Genomic

  1. NC_072378.2 Reference NHGRI_mPonPyg2-v2.0_pri Primary Assembly

    Range
    31898655..31901476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054491396.2 → XP_054347371.1  tumor necrosis factor isoform X2

  2. XM_054491395.2 → XP_054347370.1  tumor necrosis factor isoform X1

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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