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TNF tumor necrosis factor [ Chelonoidis abingdonii (Abingdon island giant tortoise) ]

Gene ID: 116822853, updated on 18-Mar-2024

Summary

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Gene symbol
TNF
Gene description
tumor necrosis factor
Gene type
protein coding
RefSeq status
MODEL
Organism
Chelonoidis abingdonii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira; Testudinoidea; Testudinidae; Chelonoidis
Orthologs
human mouse all
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Genomic context

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See TNF in Genome Data Viewer
Location:
chromosome: Un
Exon count:
4
Annotation release Status Assembly Chr Location
100 current ASM359739v1 (GCF_003597395.1) Unplaced Scaffold NW_022641572.1 (67992..73004, complement)

NW_022641572.1Genomic Context describing neighboring genes Neighboring gene leukocyte specific transcript 1 Neighboring gene antigen-presenting glycoprotein CD1d-like Neighboring gene lymphotoxin-alpha-like Neighboring gene TNF receptor-associated factor 2-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_022641572 Unplaced Scaffold Reference ASM359739v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables CD40 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Chelonoidis abingdonii Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM359739v1

Genomic

  1. NW_022641572.1 Reference ASM359739v1

    Range
    67992..73004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_032777003.1 → XP_032632894.1  tumor necrosis factor isoform X2

    UniProtKB/TrEMBL
    A0A8C0G5P3
    Conserved Domains (1) summary
    pfam00229
    Location:102 → 233
    TNF; TNF(tumor Necrosis Factor) family

  2. XM_032777002.1 → XP_032632893.1  tumor necrosis factor isoform X1

    UniProtKB/TrEMBL
    A0A8C0G5P3
    Conserved Domains (1) summary
    pfam00229
    Location:103 → 234
    TNF; TNF(tumor Necrosis Factor) family
Nucleotide Protein
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