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TNF tumor necrosis factor [ Orcinus orca (killer whale) ]

Gene ID: 101269870, updated on 8-Mar-2024

Summary

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Gene symbol
TNF
Gene description
tumor necrosis factor
See related
EnsemblRapid:ENSOORG00010009873
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Also known as
TNFA
Orthologs
human mouse all
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Genomic context

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See TNF in Genome Data Viewer
Location:
chromosome: 10
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 10 NC_064568.1 (82782262..82785037, complement)

Chromosome 10 - NC_064568.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC125965566 Neighboring gene leukocyte specific transcript 1 Neighboring gene lymphotoxin beta Neighboring gene lymphotoxin alpha Neighboring gene NFKB inhibitor like 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064568.1 Chromosome 10 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables CD40 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor
Names
tumor necrosis factor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064568.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    82782262..82785037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004286610.1 → XP_004286658.1  tumor necrosis factor

    See identical proteins and their annotated locations for XP_004286658.1

    UniProtKB/TrEMBL
    K9JA64
    Related
    ENSOORP00010012335.1, ENSOORT00010014519.1
    Conserved Domains (1) summary
    pfam00229
    Location:103 → 233
    TNF; TNF(tumor Necrosis Factor) family
Nucleotide Protein
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