This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …

… T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
… Therefore, stringent regulation of T cell activation is crucial for T cell homeostasis and proper …

… We provide figures showing the predicted T cell activation for … have established that T cell
activation is determined by the … to T cell activation that is consistent with the published data. …

… provides an essentialstructural support for T cell activation(3–6).The … changes that occurduring
T cell activation and cover recent … pathways and thecytoskeleton drive T cell activation. …

The activation of T cells mediated by the T cell antigen receptor (TCR) requires the interaction
of dozens of proteins, and its malfunction has pathological consequences. Our major focus …

… proliferation can be used as a readout for T cell activation. Regulation of T cell function can
… a convenient measure of T cell activation. A second phase of T cell activation is proliferation, …

… Historically, it has been assumed that T-cell activation in the rheumatoid joint would be … in
which T-cell activation and effector responses are driven by proinflammatory cytokines (Fig. 2). …

… Glycosylation patterns of cell‐surface proteins affect the distribution of the TCR during antigen
presentation and hence establish a threshold for T cell activation. Naive lymphocytes are …

… our understanding of how the cytoskeleton controls T-cell activation (Table 1). From this …
on the current models of cytoskeletal control over T-cell activation during APC recognition. …

… In anattempt to define a role for PKCθ in T cell activation, we initiallyturned our attention
to the potential function of PKCθ as an upstreamregulator of AP-1. Stable overexpression of …