Solid-state pharmaceutical chemistry
SR Byrn, RR Pfeiffer, G Stephenson… - Chemistry of …, 1994 - ACS Publications
… The study of the solid-state chemistry of drugs not only encompasses many scientific
disciplines but also impinges on virtually all phases of the pharmaceutical industry, from discovery …
disciplines but also impinges on virtually all phases of the pharmaceutical industry, from discovery …
Molecular perspectives on solid-state phase transformation and chemical reactivity of drugs: metoclopramide as an example
SY Lin - Drug discovery today, 2015 - Elsevier
… The solid-state chemistry of drugs has received major attention from the pharmaceutical
industry … The solid-state chemistry of drugs is a broad field covering many scientific disciplines, …
industry … The solid-state chemistry of drugs is a broad field covering many scientific disciplines, …
Solid state organic chemistry and drug stability
SR Byrn - Annual Reports in Medicinal Chemistry, 1985 - Elsevier
… A variety of methods are available for the study of solid state organic chemistry and the
solid state chemistry of drugs. These include x-ray crystallography, light microscopy, thermal …
solid state chemistry of drugs. These include x-ray crystallography, light microscopy, thermal …
Solid-State Chemistry of Drugs By Stephen R. Byrn, Academic Press, New York, NY. 1982. 346+ xii pp. 16× 23.5 cm. ISBN 0-12-148620-6. $60.00.
WH De Camp - Powder Diffraction, 1986 - cambridge.org
This isn't a book. It is a novel approach one company has elected to take to make their
product catalog more useful. This handbook is their way of sharing the knowledge they've …
product catalog more useful. This handbook is their way of sharing the knowledge they've …
[BOOK][B] Solid-state properties of pharmaceutical materials
SR Byrn, G Zografi, XS Chen - 2017 - books.google.com
… The scientific discipline of solid-state chemistry of drugs emphasizes studies of the chemical
and physical properties of the various solid forms just discussed. These studies include solid…
and physical properties of the various solid forms just discussed. These studies include solid…
New solid-state chemistry technologies to bring better drugs to market: knowledge-based decision making
A Park, LJ Chyall, J Dunlap, C Schertz… - Expert Opinion on …, 2007 - Taylor & Francis
Modern drug development demands constant deployment of more effective technologies to
mitigate the high cost of bringing new drugs to market. In addition to cost savings, new …
mitigate the high cost of bringing new drugs to market. In addition to cost savings, new …
Accelerating proof of concept for small molecule drugs using solid-state chemistry
SR Byrn, G Zografi, XS Chen - Journal of pharmaceutical sciences, 2010 - Elsevier
In this perspective we have shown that the process of“proof of concept” (POC) in the early
part of drug development can be greatly accelerated by close attention to the underlying solid-…
part of drug development can be greatly accelerated by close attention to the underlying solid-…
Relevance of solid‐state properties for pharmaceutical products
R Hilfiker, F Blatter, M Raumer - Polymorphism: in the …, 2006 - Wiley Online Library
solid form if solvates are included. When a compound is acidic or basic, it is often possible
to create a salt (Chapter 12) with a suitable base or acid, and such a salt can in turn often be …
to create a salt (Chapter 12) with a suitable base or acid, and such a salt can in turn often be …
Impact of solid-state characteristics to the physical stability of drug substance and drug product
Y Guo - Handbook of stability testing in pharmaceutical …, 2009 - Springer
In the drug development and commercialization process, the acceptable stability of the drug
substance and drug product is one of the basic requirements for clinical studies, regulatory …
substance and drug product is one of the basic requirements for clinical studies, regulatory …
Solid-state analysis of the active pharmaceutical ingredient in drug products
AW Newman, SR Byrn - Drug discovery today, 2003 - Elsevier
The solid form of a drug substance is important when developing a new chemical entity. The
crystalline form used in development is significant based on possible manufacturability, …
crystalline form used in development is significant based on possible manufacturability, …
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