Solid form screening, the activity of generating and analysing different solid forms of an active
pharmaceutical ingredient (API), has become an essential part of drug development. The …

Most active pharmaceutical ingredients (APIs) are solid in nature and could exist in many
forms that vary significantly in their properties, leading to different physical, chemical, …

Within the pharmaceutical industry, and elsewhere, the screening for new solid forms is a
mandatory exercise for both existing and new chemical entities. This contribution focuses on …

In recent years, solid form screening has become an integral and mandatory part of drug
development. Solid form screening typically involves producing and characterizingmaximum …

Despite the wide occurrence of crystallization in the pharmaceutical industry, deep
understanding and fine control of the process remain a tricky issue. Nevertheless, the successful …

The expansion of a novel product is constrained by an active medicinal ingredient's poor
solubility in aqueous solutions and limited oral bioavailability. A novel strategy to improve the …

A porous, nonsolvated polymorph of the voltage-gated sodium channel blocker mexiletine
hydrochloride absorbs iodine vapor to give a pharmaceutical cocrystal incorporating an I 2 Cl …

Cocrystals are crystalline single phase materials composed of two or more different molecular
and/or ionic compounds generally in a stoichiometric ratio which are neither solvates nor …

The administration of compounds by a dry-powder inhaler presents significant challenges to
the development and discovery chemist, owing to the stringent requirements placed upon …

High-throughput (HT) techniques built upon laboratory automation technology and coupled
to statistical experimental design and parallel experimentation have enabled the …