The tumor-suppressor protein p53 has been called the “Cellular Gatekeeper” and a “Guardian
of the Genome” for its well-documented activities in causing cell cycle arrest and …

… While we have shown that phosphorylation is not essential for the transcriptional function
of p53, it is possible that subtle levels of regulation of p53 function through phosphorylation …

… Moreover, by substituting serine for each cysteine in murine p53, we have investigated
the roles of individual cysteines in the regulation of p53 function. Substitution of serine for …

The reversible and dynamic methylation of proteins on lysine residues can greatly increase
the signaling potential of the modified factor. In addition to histones, several other nuclear …

Thep53 tumour suppressor gene acts to prevent the development of cancer (Donehower et
al., 1992). It does so as “the guardian of the genome”(Lane, 1992) by blocking the division of …

The gene termed p53 is one of the most extensively studied for the past 18 years and the
amount of literature published on this gene reflects its relevance in the field of molecular …

Despite intensive study of p53, the regulation of p53 cellular localization is still poorly understood.
This is an overview of the elements and molecules involved in p53 nucleocytoplasmic …

… Tight regulation of p53 function is critical for normal cell growth and development, and one
mechanism by which p53 function is controlled is through interaction with the Mdm2 protein““. …

The p53 protein is one of the most important tumor suppressor proteins. Normally, the p53
protein is in a latent state. However, when its activity is required, eg upon DNA damage, …

The p53 tumor suppressor protein plays a key role in the regulation of the cell cycle and cell
death. The p53 protein is also involved in cell differentiation, DNA repair, senescence and …