Ryanodine receptor calcium release channels

M Fill, JA Copello - Physiological reviews, 2002 - journals.physiology.org
… Environment of the ryanodine receptor channel in skeletal muscle. The t tubule contains
tetrads of dihydropyridine receptors (DHPRs). Every other RyR1 channel is associated with a …

[PDF][PDF] The ryanodine receptor/Ca2+ release channel

PS McPherson, KP Campbell - J Biol Chem, 1993 - physiology.uiowa.edu
… as the ryanodine receptor, but only recently has the ryanodine receptor been recognized
as … This review will examine the role of the ryanodine receptor as a component of excitation…

Ryanodine receptor structure: progress and challenges

SL Hamilton, II Serysheva - Journal of Biological Chemistry, 2009 - ASBMB
Ryanodine-sensitive Ca2 release channels, also known as the ryanodine receptors (RyRs),
2 are homotetramers of an 550-kDa subunit (Fig. 1) that are resident proteins of intracellular …

Ryanodine receptor physiology and its role in disease

JT Lanner - Calcium Signaling, 2012 - Springer
The ryanodine receptors (RyRs) is the major intracellular Ca 2+ release channel localized in
the plasma membrane of the endoplasmatic/sarcoplasmatic reticulum. RyR-mediated Ca 2…

Structure of a mammalian ryanodine receptor

R Zalk, OB Clarke, A Des Georges, RA Grassucci… - Nature, 2015 - nature.com
… The type 1 ryanodine receptor (RyR1) mediates excitation–contraction coupling in skeletal
muscle. It is a homotetramer of four ∼565-kilodalton (kDa) channel-forming protomers, as …

The structural basis of ryanodine receptor ion channel function

G Meissner - Journal of General Physiology, 2017 - rupress.org
Large-conductance Ca 2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca 2+ from an intracellular membrane compartment, the endo/sarcoplasmic …

The ryanodine receptor in cardiac physiology and disease

A Kushnir, AR Marks - Advances in pharmacology, 2010 - Elsevier
… Over the past 20 years advances in the field of ryanodine receptor (RyR2)/calcium release
channel research have greatly advanced our understanding of cardiac physiology and the …

Ryanodine receptor structure and function in health and disease

G Santulli, D Lewis, A des Georges, AR Marks… - … : structure and function, 2018 - Springer
Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca 2+ ) release channels
required for the function of many organs including heart and skeletal muscle, synaptic …

Modulation of the ryanodine receptor and intracellular calcium

R Zalk, SE Lehnart, AR Marks - Annu. Rev. Biochem., 2007 - annualreviews.org
Ryanodine receptors (RyRs)/Ca 2+ release channels, on the endoplasmic and sarcoplasmic
reticulum of most cell types, are required for intracellular Ca 2+ release involved in diverse …

Molecular regulation of cardiac ryanodine receptor ion channel

G Meissner - Cell calcium, 2004 - Elsevier
The release of Ca 2+ ions from intracellular stores is a key step in a wide variety of cellular
functions. In striated muscle, the release of Ca 2+ from the sarcoplasmic reticulum (SR) leads …