Safety of polysorbate 80 in the oncology setting

LS Schwartzberg, RM Navari - Advances in therapy, 2018 - Springer
… (IV) infusion of docetaxel 35 mg/m 2 (polysorbate 80 1.75 g) showed a polysorbate 80 peak
concentration of 304 μg/ml [18]. The AUC for polysorbate 80 was 321.7 mg h/ml, with a short …

Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

EA Coors, H Seybold, HF Merk, V Mahler - Annals of Allergy, Asthma & …, 2005 - Elsevier
… Results: Polysorbate 80 was identified as the causative agent for the … Conclusions: Polysorbate
80 is a ubiquitously used … We identified polysorbate 80, which is generally believed to …

Polysorbate 80 and E-Ferol toxicity

SL Alade, RE Brown, A Paquet Jr - Pediatrics, 1986 - publications.aap.org
… Because a mixture of polysorbate 80 and polysorbate 20 is used as a carrier in E-Ferol, …
for the suppression, especially the polysorbate 80. Concurrent with this suppression of PHA-…

Peroxide formation in polysorbate 80 and protein stability

E Ha, W Wang, YJ Wang - Journal of pharmaceutical sciences, 2002 - Elsevier
… Instead of using neat polysorbate 80, we prepared 20% polysorbate 80 solutions for stability
studies because the peroxide formation is faster and any effect can be observed in a shorter …

Polysorbate 80: a pharmacological study.

RK Varma, R Kaushal, AY Junnarkar… - Arzneimittel …, 1985 - europepmc.org
… (polysorbate 80, Tween 80), a surfactant, has been widely used as a solvent for pharmacological
experiments. In the present study, polysorbate 80Polysorbate 80 did not have a direct …

Effect of polysorbate 80 concentration on thermal and photostability of a monoclonal antibody

M Agarkhed, C O'Dell, MC Hsieh, J Zhang… - Aaps Pharmscitech, 2013 - Springer
… Our results show that Polysorbate 80 concentration of 1.00% (w/v) adversely … Polysorbate
80 concentration in protein formulations to prevent destabilizing effect of Polysorbate 80 on …

Analysis of polysorbate 80 and its related compounds by RP-HPLC with ELSD and MS detection

R Zhang, Y Wang, L Tan, HY Zhang… - Journal of …, 2012 - academic.oup.com
… Figure 2 shows the process of synthesizing polysorbate 80. In this process, sorbitol was first
… oxide to yield polysorbate 80. The synthetic process implies that polysorbate 80, primarily …

Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain

W Sun, C Xie, H Wang, Y Hu - Biomaterials, 2004 - Elsevier
It was reported that nanoparticles with polysorbate 80 (Tween 80, T-80) coating represented
tools used for delivering drugs to brain. Nevertheless, disputations were once aroused for …

Molecular dynamics simulation of a polysorbate 80 micelle in water

A Amani, P York, H de Waard, J Anwar - Soft Matter, 2011 - pubs.rsc.org
… of a single polysorbate 80 molecule and the self-assembly of sixty polysorbate 80 molecules
in … Molecular simulation of polysorbate 80 micelles presents somewhat of a challenge as the …

Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles

AE Gulyaev, SE Gelperina, IN Skidan… - Pharmaceutical …, 1999 - Springer
… particles overcoated with 1% polysorbate 80 (Tween® 80). … nanoparticles overcoated
with polysorbate 80 between 2 and … with the nonionic surfactant polysorbate 80. It is highly …