The multisubunit enzymes of the complement system that cleave C5 have many unusual
properties, the most striking of which is that they acquire their specificity for C5 following …

Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen
lysis, inflammation and cell damage. The therapeutic potential of C5 inhibition has been …

… Functional role of the noncatalytic subunit of complement C5 convertase. J Immunol 2000; …
The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA…

Components of innate immunity have recently been implicated in the regulation of
developmental processes. Most strikingly, complement factors appear to be involved in limb …

… Plasma levels of complement C5 were analyzed in relation to the presence of generalized
(>2 plaques) or incipient (0 to 2 plaques) subclinical atherosclerosis in 2 independent clinical …

Renal fibrosis is the final common pathway of most progressive renal diseases. C5 was
recently identified as a risk factor for liver fibrosis. This study investigated the role of C5 in the …

Activated plasma complement will induce biphasic aggregation of human granulocytes
dectable by standard nephelometric techniques. The responsible active component was …

Respiratory failure and acute kidney injury (AKI) are associated with high mortality in SARS-CoV-2-associated
Coronavirus disease 2019 (COVID-19). These manifestations are linked …

… All activation pathways lead to generation of a C3 convertase, and subsequently to formation
of a complement C5 convertase which cleaves C5 into C5a (residues 678–751) and C5b. …

Complement C5 inhibition is the standard of care (SoC) for patients with paroxysmal
nocturnal hemoglobinuria (PNH) with significant clinical symptoms. Constant and complete …