We report a two-color, cell-based screen to identify specific receptor-binding compounds in a
combinatorial library of peptoids displayed on beads. We apply this strategy to the isolation …

… to proteolysis, may enable it a new generation of artificial antibody surrogate. Furthermore,
our strategy of artificial antibody surrogate based on dimers of cyclic γ-AApeptides could be …

Background Trypanosoma cruzi parasite, the causative agent of Chagas disease, infects
about six million individuals in more than 20 countries. Monitoring parasite persistence in …

… To comprehensively assess the potential liability of TNFα suppression on reproductive and
developmental processes, a PEGylated Fab′ anti-rat TNFα antibody surrogate (cTN3 PF) …

… In particular, the Medicines and Healthcare products Regulatory Agency (MHRA) of the UK
has announced that neutralizing antibody surrogate endpoints established using the WHO …

Bispecific antibodies (bsAbs) are emerging immune-therapeutics, and many formats exist
that differ considerably in structure. However, little systematic data exist about how the spatial …

Background and Purpose Polatuzumab vedotin is an antibody–drug conjugate (ADC) being
developed for non‐Hodgkin's lymphoma. It contains a humanized anti‐CD79b IgG1 …

… These data suggest that the bacterially produced tetrameric ASA can be used as an
antibody-surrogate molecule. This class of molecule will play a role in the diagnosis and treatment of …

… Indeed, multiple vaccine developers are pursuing this approach that characterizes an antibody
surrogate endpoint in multiple sero-epidemiological natural history observational studies …

… In this case, the embryo-fetal development study with the PDGFRα antibody surrogate
molecule LSN3338786 demonstrated a limited increase in malformations (open and partially …