The ability to discriminate self from non-self is a fundamental property of the immune system.
In the case of T lymphocytes, the first level of this discrimination takes place in the thymus, …

Peripheral T cell maintenance requires a survival signal delivered upon T cell receptor (TCR)-major
histocompatibility complex (MHC) molecule interaction. Since self-peptides play a …

T lymphocyte development and differentiation is a multi-step process that begins in the thymus
and completed in the periphery. Sequential development of thymocytes is dependent on …

In this report we are reviewing principal data on development of T cell lineage in the thymus
and some intrathymic factors. The review is concentrated on the main events of T cell …

Despite the potentially vast T-cell repertoire, biased αβ T-cell receptor (TCR) usage has
emerged as a common theme in immunity. Examples of TCR bias are observed in classical …

CD8 plays an important role in facilitating TCR-MHC interaction, promoting Ag recognition,
and initiating T cell activation. MHC-CD8 binding kinetics have been measured in three …

CD4 memory T cells surviving in the absence of MHC class II contact lose their characteristic
memory function. To investigate the mechanisms underlying the impaired function of …

The T cell receptor (TCR) repertoire is diverse, thus allowing recognition of a wide range of
pathogens by T cells. In humans, the study of the formation of TCR repertoires is problematic …

Human embryonic stem cells (hESCs) are envisioned to be a major source for cell‐based
therapies. Efforts to overcome rejection of hESCs include nuclear transfer and collection of …

The major histocompatibility complex (MHC) harbours genes whose primary function in
regulating immune responsiveness to infection is to present foreign antigens to cytotoxic T …