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Effects of overexpressing folding modulators on the in vivo folding of heterologous proteins in Escherichia coli.

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Affiliations

  • 1. University of Zürich, Switzerland.
      Authors
    • Wall JG 1
    (1 author)

ORCIDs linked to this article

Current Opinion in Biotechnology, 01 Oct 1995, 6(5):507-516
https://doi.org/10.1016/0958-1669(95)80084-0 PMID: 7579662 

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Abstract 

Interest continues to increase in the use of folding modulators to overcome problems with heterologous protein folding in Escherichia coli. Currently, this approach, though highly successful with a number of individual proteins, remains a somewhat hit-and-miss affair. Ongoing research directed at unraveling the precise role and specificity of these folding modulators should generate a clearer understanding of the potential and limitations of overexpressing folding catalysts in vivo. This will facilitate the development, in the not too distant future, of a more structured and rational approach to improving the folding of heterologous gene products in E. coli.

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Read article at publisher's site: https://doi.org/10.1016/0958-1669(95)80084-0

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