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Methenamine mandelate with acidification: an effective urinary antiseptic in patients with neurogenic bladder.

Mayo Clinic Proceedings, 01 Aug 1984, 59(8):523-529
https://doi.org/10.1016/s0025-6196(12)61489-x PMID: 6379319 

Abstract 

We studied the effectiveness of methenamine mandelate in preventing urinary tract infection in patients with neurogenic bladder dysfunction who were in a program of intermittent catheterization and bladder retraining. Nine of 17 patients (53%) became infected while receiving the drug, whereas 19 of 22 patients (86%) in a placebo group became infected during the trial. The difference in infection rates was statistically significant (P less than 0.02) and resulted primarily from the absence of gram-positive cocci and Pseudomonas species in the drug group.

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Read article at publisher's site: https://doi.org/10.1016/s0025-6196(12)61489-x

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