Monoclonal antibodies which recognize different cell types in the rat retina.

Abstract

Seven monoclonal antibodies have been produced against a membrane preparation from adult rat retina. Three antibodies reacted with particular regions of rat photoreceptor cell surfaces: RET-P1 labelled the cell bodies, outer and inner segments (rods but not cones), RET-P2 labelled only outer segments and RET-P3 labelled only the cell bodies. Three antibodies reacted with glial cells; RET-G2 and RET-G3 were specific for Müller cells, RET-G1 also labelled glia elsewhere in brain. The seventh antibody (RET-N1) reacted with many types of neuronal cells.

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References

Articles referenced by this article (41)

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Abstract

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References

Sidman, R. L. 3rd Lepetit Colloquium on Cell Interactions (ed. Silvestri, L. G.), 1–13 (North-Holland, Amsterdam, 1972).

Moscona, A. A. (ed.) The Cell Surface in Development (Wiley, New York, 1974).

Rutishauser, V., Brackenbury, R., Thiery, J. P. & Edelman, G. M. Birth Defects: Original Article Series XIV, 305–316 (1978).

Krnjevic, K. Physiol. Rev. 54, 418–540 (1974).

Hall, Z., Kelly, R. & Fox, C. F. (eds) Cellular Neurobiology (Liss, New York, 1977).

New cell surface antigens in rat defined by tumors of the nervous system.

Histological localization of nervous-system antigens in the cerebellum by immunoperoxidase labeling.

Correlation of surface antigens and cell type in cloned cell lines from the rat central nervous system.

Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture.

Continuous cultures of fused cells secreting antibody of predefined specificity.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1038/286231a0

Article citations

Inhibition of Epigenetic Modifiers LSD1 and HDAC1 Blocks Rod Photoreceptor Death in Mouse Models of Retinitis Pigmentosa.

Inner retinal preservation in the photoinducible I307N rhodopsin mutant mouse, a model of autosomal dominant retinitis pigmentosa.

A Defective Crosstalk Between Neurons and Müller Glial Cells in the rd1 Retina Impairs the Regenerative Potential of Glial Stem Cells.

The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development.

Specialized photoreceptor composition in the raptor fovea.

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