Chromosomal localization of three human ras genes by in situ molecular hybridization.

Abstract

Three human ras family protooncogenes, c-Ki-ras-1, and c-Ki-ras-2, and N-ras, have been mapped to chromosome bands 6p11-12, 12p11.1-12.1, and 1p11-13, respectively by in situ molecular hybridization. Certain human cancers display consistent and specific alterations involving chromosomes 1, 6, and 12. The precise chromosomal localization of ras genes will permit evaluation of the possible effect of these chromosome changes on the structure and activities of ras protooncogenes in human neoplasia.

Full text links

Read article at publisher's site: https://doi.org/10.1007/bf01534703

References

Articles referenced by this article (59)

Fewer and fewer oncogenes.
Weinberg RA
Cell, (1):3-4 1982
MED: 6751559
Cellular transforming genes.
Cooper GM
Science, (4562):801-806 1982
MED: 6285471
Oncogenes in solid human tumours.
Pulciani S, Santos E, Lauver AV, Long LK, Aaronson SA, Barbacid M
Nature, (5892):539-542 1982
MED: 7144906
T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes.
Santos E, Tronick SR, Aaronson SA, Pulciani S, Barbacid M
Nature, (5872):343-347 1982
MED: 6283384
Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.
Der CJ, Krontiris TG, Cooper GM
Proc Natl Acad Sci U S A, (11):3637-3640 1982
MED: 6285355
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line.
Shimizu K, Goldfarb M, Perucho M, Wigler M
Proc Natl Acad Sci U S A, (2):383-387 1983
MED: 6300838
Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene.
Parada LF, Tabin CJ, Shih C, Weinberg RA
Nature, (5866):474-478 1982
MED: 6283357
Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype.
Eva A, Tronick SR, Gol RA, Pierce JH, Aaronson SA
Proc Natl Acad Sci U S A, (16):4926-4930 1983
MED: 6308661
Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses.
Chang EH, Gonda MA, Ellis RW, Scolnick EM, Lowy DR
Proc Natl Acad Sci U S A, (16):4848-4852 1982
MED: 6289320
Structure and activation of the human N-ras gene.
Taparowsky E, Shimizu K, Goldfarb M, Wigler M
Cell, (2):581-586 1983
MED: 6616621

Show 10 more references (10 of 59)

Citations & impact

Impact metrics

45

Citations

Jump to Citations

4

Data citations

Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/3411104

Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/3411104

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1007/bf01534703

Supporting

Mentioning

Contrasting

0

30

0

Article citations

Characteristics and prognostic analysis of patients with detected KRAS mutations in resected lung adenocarcinomas by peptide nucleic acid-locked nucleic acid polymerase chain reaction (PNA-LNA PCR) clamp method.
Hashimoto T, Owada Y, Katagiri H, Yakuwa K, Tyo K, Sugai M, Fuzimura I, Utsumi Y, Akiyama M, Nagashima H, Terasaki H, Yanagawa N, Saito H, Sugai T, Maemondo M
Transl Lung Cancer Res, 12(9):1862-1875, 15 Sep 2023
Cited by: 0 articles | PMID: 37854155 | PMCID: PMC10579836
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence.
Murali R, Balasubramaniam V, Srinivas S, Sundaram S, Venkatraman G, Warrier S, Dharmarajan A, Gandhirajan RK
Metabolites, 13(4):560, 15 Apr 2023
Cited by: 5 articles | PMID: 37110218 | PMCID: PMC10141515
Review
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Drugging KRAS: current perspectives and state-of-art review.
Parikh K, Banna G, Liu SV, Friedlaender A, Desai A, Subbiah V, Addeo A
J Hematol Oncol, 15(1):152, 25 Oct 2022
Cited by: 31 articles | PMID: 36284306 | PMCID: PMC9597994
Review
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Unlike in clear cell renal cell carcinoma, KRAS is not mutated in multilocular cystic clear cell renal cell neoplasm of low potential.
Raspollini MR, Castiglione F, Martignoni G, Cheng L, Montironi R, Lopez-Beltran A
Virchows Arch, 467(6):687-693, 05 Oct 2015
Cited by: 7 articles | PMID: 26438300
Does BRAF Mutation and Extracellular Signal Regulated Kinase Expression in Patients With Colorectal Cancer Have Any Prognostic Significance?
Baek MJ
Ann Coloproctol, 31(1):1-2, 01 Feb 2015
Cited by: 1 article | PMID: 25745617 | PMCID: PMC4349910
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC

Go to all (45) article citations

Data

Data that cites the article

This data has been provided by curated databases and other sources that have cited the article.

Diseases in OMIM (3)

V-KI-RAS2 KIRSTEN RAT SARCOMA VIRAL ONCOGENE HOMOLOG; KRAS(OMIM - 190070)
NEUROBLASTOMA RAS VIRAL ONCOGENE HOMOLOG; NRAS(OMIM - 164790)
V-HA-RAS HARVEY RAT SARCOMA VIRAL ONCOGENE HOMOLOG; HRAS(OMIM - 190020)

Mouse Genome Informatics (MGI)

http://www.informatics.jax.org/reference/3856955

Search life-sciences literature (45,090,497 articles, preprints and more)

Abstract

Full text links

References

Fewer and fewer oncogenes.

Cellular transforming genes.

Oncogenes in solid human tumours.

T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes.

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line.

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene.

Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype.

Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses.

Structure and activation of the human N-ras gene.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1007/bf01534703

Article citations

Characteristics and prognostic analysis of patients with detected KRAS mutations in resected lung adenocarcinomas by peptide nucleic acid-locked nucleic acid polymerase chain reaction (PNA-LNA PCR) clamp method.

Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence.

Drugging KRAS: current perspectives and state-of-art review.

Unlike in clear cell renal cell carcinoma, KRAS is not mutated in multilocular cystic clear cell renal cell neoplasm of low potential.

Does BRAF Mutation and Extracellular Signal Regulated Kinase Expression in Patients With Colorectal Cancer Have Any Prognostic Significance?

Data

Data that cites the article

Diseases in OMIM (3)

Mouse Genome Informatics (MGI)

Similar Articles

Localization of c-ras oncogene family on human germ-line chromosomes.

Chromosome mapping of genes on the short arm of human chromosome 11: parathyroid hormone gene is at 11p15 together with the genes for insulin, c-Harvey-ras 1, and beta-hemoglobin.

Regional chromosomal localization of N-ras, K-ras-1, K-ras-2 and myb oncogenes in human cells.

Chromosomal localization of protooncogenes.

Partnerships & funding