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Influence of previous Zika virus infection on acute dengue episode.

Author information

Affiliations

  • 1. Laboratório de Pesquisas em Virologia (LPV), Faculdade de Medicina de São José do Rio Preto (FAMERP); São José do Rio Preto, Sao Paulo, Brazil.
      Authors
    • Estofolete CF 1
    • Versiani AF 1, 6
    • Dourado FS 1
    • Milhim BHGA 1
    • Pacca CC 1
    • Silva GCD 1
    • Zini N 1
    • Santos BFD 1
    • Gandolfi FA 1
    • Mistrão NFB 1
    • Garcia PHC 1
    • Rocha RS 1
    • Nogueira ML 1, 6
    (13 authors)
  • 2. Institute for Medical Engineering and Science, Massachusetts Institute of Technology; Cambridge, Massachusetts, United States of America.
      Authors
    • Gehrke L 2
    • Bosch I 2
    (2 authors)
  • 3. Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM); Campinas, Sao Paulo, Brazil.
      Authors
    • Marques RE 3
    (1 author)
  • 4. Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais; Belo Horizonte, Minas Gerais, Brazil.
      Authors
    • Teixeira MM 4
    (1 author)
  • 5. Laboratório de Virologia Básica e Aplicada, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais; Belo Horizonte, Minas Gerais, Brazil.
      Authors
    • da Fonseca FG 5
    (1 author)
    • Show all (6)

ORCIDs linked to this article

Plos Neglected Tropical Diseases, 09 Nov 2023, 17(11):e0011710
https://doi.org/10.1371/journal.pntd.0011710 PMID: 37943879 PMCID: PMC10662752

This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Abstract 

Background

The co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study investigated the influence of antibodies generated by previous Zika infection on the clinical outcomes of dengue infection.

Methodology/principal findings

We enrolled 1,043 laboratory confirmed dengue patients and investigated their prior infection to Zika or dengue. Severe forms of dengue disease were more frequent in patients with previous Zika infection, but not in those previously exposed to dengue.

Conclusions/significance

Our findings suggest that previous Zika infection may represent a risk factor for subsequent severe dengue disease, but we did not find evidence of antibody-dependent enhancement (higher viral titer or pro-inflammatory cytokine overexpression) contributing to exacerbation of the subsequent dengue infection.

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Read article at publisher's site: https://doi.org/10.1371/journal.pntd.0011710

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Data 

Data behind the article

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Genes & Proteins

Nucleotide Sequences (4)

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Funding 

Funders who supported this work.

CNPq

    CREID

      Conselho Nacional de Desenvolvimento Científico e Tecnológico (1)

      Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (1)

      Fundação de Amparo à Pesquisa do Estado da Bahia (1)

      Fundação de Amparo à Pesquisa do Estado de São Paulo (2)

      INCT (1)

      NIAID NIH HHS (1)