Europe PMC
Nothing Special   »   [go: up one dir, main page]

Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Investigating Associations of Omega-3 Fatty Acids, Lung Function Decline, and Airway Obstruction.

Show less

Author information

Affiliations

  • 1. Division of Nutritional Sciences, Cornell University, Ithaca, New York.
      Authors
    • Patchen BK 1
    • Cassano PA 1
    (2 authors)
  • 2. Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
      Authors
    • Balte P 2
    • Barr RG 2
    • Oelsner E 2
    (3 authors)
  • 3. Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health.
      Authors
    • Bartz TM 3
    • Lemaitre RN 3
    • Psaty B 3
    (3 authors)
  • 4. Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas.
      Authors
    • Fornage M 4
    • North K 4
    (2 authors)
  • 5. Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.
      Authors
    • Graff M 5
    • Seo J 5
    • Steffen LM 5
    (3 authors)
    • Show all (14)

ORCIDs linked to this article

Show all (7)

American Journal of Respiratory and Critical Care Medicine, 01 Oct 2023, 208(8):846-857
https://doi.org/10.1164/rccm.202301-0074oc PMID: 37470492 

This is an update of "" medRxiv. 2023 Jan 18:2023.01.18.23284671. doi: 10.1101/2023.01.18.23284671. A comment on this article appears in "The Protective Effect of Omega-3 Fatty Acids in Attenuating Lung Function Decline." Am J Respir Crit Care Med. 2023 Oct 15;208(8):828-830. doi: 10.1164/rccm.202307-1222ED. This article is based on a previously available preprint.

Abstract 

Rationale: Inflammation contributes to lung function decline and the development of chronic obstructive pulmonary disease. Omega-3 fatty acids have antiinflammatory properties and may benefit lung health. Objectives: To investigate associations of omega-3 fatty acids with lung function decline and incident airway obstruction in a diverse sample of adults from general-population cohorts. Methods: Complementary study designs: 1) longitudinal study of plasma phospholipid omega-3 fatty acids and repeated FEV1 and FVC measures in the NHLBI Pooled Cohorts Study and 2) two-sample Mendelian randomization (MR) study of genetically predicted omega-3 fatty acids and lung function parameters. Measurements and Main Results: The longitudinal study found that higher omega-3 fatty acid levels were associated with attenuated lung function decline in 15,063 participants, with the largest effect sizes for the most metabolically downstream omega-3 fatty acid, docosahexaenoic acid (DHA). An increase in DHA of 1% of total fatty acids was associated with attenuations of 1.4 ml/yr for FEV1 (95% confidence interval [CI], 1.1-1.8) and 2.0 ml/yr for FVC (95% CI, 1.6-2.4) and a 7% lower incidence of spirometry-defined airway obstruction (95% CI, 0.89-0.97). DHA associations persisted across sexes and smoking histories and in Black, White, and Hispanic participants, with associations of the largest magnitude in former smokers and Hispanic participants. The MR study showed similar trends toward positive associations of genetically predicted downstream omega-3 fatty acids with FEV1 and FVC. Conclusions: The longitudinal and MR studies provide evidence supporting beneficial effects of higher levels of downstream omega-3 fatty acids, especially DHA, on lung health.

Full text links 

Read article at publisher's site: https://doi.org/10.1164/rccm.202301-0074oc

Citations & impact 

Impact metrics

10
Citations
Jump to Citations

Citations of article over time

Article citations

Go to all (10) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

NHLBI NIH HHS (10)

NIDDK NIH HHS (2)

National Heart, Lung, and Blood Institute (1)

National Institute of Diabetes and Digestive and Kidney Diseases (1)