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Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis.

Author information

Affiliations

  • 1. Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland.
      Authors
    • McMackin R 1
    • Dukic S 1
    • Costello E 1
    • McManus L 1
    • Heverin M 1
    • Nasseroleslami B 1
    (6 authors)
  • 2. Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland; Department of Neurology, University Medical Centre Utrecht Brain Centre, Utrecht University, Utrecht, The Netherlands.
      Authors
    • Pinto-Grau M 2
    (1 author)
  • 3. Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland.
      Authors
    • Broderick M 3
    (1 author)
  • 4. Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland; Computational Neuroimaging Group, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland.
      Authors
    • Chipika R 4
    • Bede P 4
    (2 authors)
  • 5. Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland; Beaumont Hospital Dublin, Department of Neurology, Dublin 9, Ireland.
      Authors
    • Iyer PM 5
    • Hardiman O 5
    (2 authors)
    • Show all (7)

ORCIDs linked to this article

Neurobiology of Aging, 10 Mar 2021, 104:57-70
https://doi.org/10.1016/j.neurobiolaging.2021.03.002 PMID: 33964609 

Abstract 

We aimed to quantitatively characterize progressive brain network disruption in Amyotrophic Lateral Sclerosis (ALS) during cognition using the mismatch negativity (MMN), an electrophysiological index of attention switching. We measured the MMN using 128-channel EEG longitudinally (2-5 timepoints) in 60 ALS patients and cross-sectionally in 62 healthy controls. Using dipole fitting and linearly constrained minimum variance beamforming we investigated cortical source activity changes over time. In ALS, the inferior frontal gyri (IFG) show significantly lower baseline activity compared to controls. The right IFG and both superior temporal gyri (STG) become progressively hyperactive longitudinally. By contrast, the left motor and dorsolateral prefrontal cortices are initially hyperactive, declining progressively. Baseline motor hyperactivity correlates with cognitive disinhibition, and lower baseline IFG activities correlate with motor decline rate, while left dorsolateral prefrontal activity predicted cognitive and behavioural impairment. Shorter survival correlates with reduced baseline IFG and STG activity and later STG hyperactivation. Source-resolved EEG facilitates quantitative characterization of symptom-associated and symptom-preceding motor and cognitive-behavioral cortical network decline in ALS.

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Read article at publisher's site: https://doi.org/10.1016/j.neurobiolaging.2021.03.002

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Funding 

Funders who supported this work.

Health Research Board (1)

Irish Research Council for Science, Engineering, and Technology

    Science Foundation Ireland